Chen Chen1, Lu-Jun Shen1, Bo-Fei Li1, Jin Gao2, Yun-Fei Xia3. 1. Department of Radiation Oncology, Sun Yat-Sen University, Guangzhou, People's Republic of China; Zhongshan School of Medcine, Sun Yat-Sen University, Guangzhou, People's Republic of China. 2. Department of Radiation Oncology, Sun Yat-Sen University, Guangzhou, People's Republic of China; State Key Laboratory of Oncology in Southern China, Cancer Center, , Sun Yat-Sen University, Guangzhou, People's Republic of China. 3. Department of Radiation Oncology, Sun Yat-Sen University, Guangzhou, People's Republic of China; State Key Laboratory of Oncology in Southern China, Cancer Center, , Sun Yat-Sen University, Guangzhou, People's Republic of China. Electronic address: xiayf@sysucc.org.cn.
Abstract
BACKGROUND AND PURPOSE: To evaluate the effect of smoking on prognosis of male nasopharyngeal carcinoma by comparing the treatment outcomes between smokers and non-smokers. MATERIALS AND METHODS: A total of 2450 nasopharyngeal carcinoma patients were enrolled, including 1865 male patients. Matching was performed between smokers and non-smokers in male patients according to age, UICC clinical stage, T stage, N stage and treatment. Survival outcomes were compared using Kaplan-Meier analysis and Cox regression. Smoking index was calculated by multiplying cigarette packs per day and smoked time (year). RESULTS: In male patients, smokers had significantly lower 5-year overall survival (70.1% vs. 77.5%, P<0.001) and locoregional recurrent free survival (76.8% vs.82.4%, P = 0.002) compared with non-smokers. Matched-pair analysis showed that smokers kept a high risk of death compared with non-smokers (HR = 2.316, P<0.001). High degree of smoking index (>15 pack-years) had a poor effect on overall survival (HR = 1.225, P = 0.016). When smoking index was more than 45 and 60 pack-years, the risk for death increased to 1.498 and 1.899 fold compared with non-smokers (P = 0.040, 0.001), respectively. CONCLUSIONS: Smoking was a poor prognostic factor for male nasopharyngeal carcinoma. The heavier the patients smoked, the poorer prognosis they suffered.
BACKGROUND AND PURPOSE: To evaluate the effect of smoking on prognosis of male nasopharyngeal carcinoma by comparing the treatment outcomes between smokers and non-smokers. MATERIALS AND METHODS: A total of 2450 nasopharyngeal carcinomapatients were enrolled, including 1865 male patients. Matching was performed between smokers and non-smokers in male patients according to age, UICC clinical stage, T stage, N stage and treatment. Survival outcomes were compared using Kaplan-Meier analysis and Cox regression. Smoking index was calculated by multiplying cigarette packs per day and smoked time (year). RESULTS: In male patients, smokers had significantly lower 5-year overall survival (70.1% vs. 77.5%, P<0.001) and locoregional recurrent free survival (76.8% vs.82.4%, P = 0.002) compared with non-smokers. Matched-pair analysis showed that smokers kept a high risk of death compared with non-smokers (HR = 2.316, P<0.001). High degree of smoking index (>15 pack-years) had a poor effect on overall survival (HR = 1.225, P = 0.016). When smoking index was more than 45 and 60 pack-years, the risk for death increased to 1.498 and 1.899 fold compared with non-smokers (P = 0.040, 0.001), respectively. CONCLUSIONS: Smoking was a poor prognostic factor for male nasopharyngeal carcinoma. The heavier the patients smoked, the poorer prognosis they suffered.