AIM: Decreased amyloid β (Aβ) clearance from the brain to blood might play a key role in the development of Alzheimer's disease (AD). Aβ is normally bound to and transported by albumin in blood, thus possibly maintaining constant concentration of free Aβ in the blood. We therefore hypothesized that decreased blood levels of albumin-Aβ complexes could be associated with decreased Aβ removal from the brain to blood, resulting in Aβ accumulation in the brain. METHODS: We carried out a cross-sectional investigation of the association between serum levels of albumin-Aβ complexes (SLAAC) and AD prevalence in 89 patients who visited our outpatient clinic, and gave written informed consent between August 2008 and May 2012. RESULTS: We confirmed 45 cases of AD. Low SLAAC was associated with an increased prevalence of AD (OR 0.27; 95% CI 0.14-0.51) in a univariable logistic model and multivariable logistic models. In addition, decreased SLAAC was associated with decreased levels of Aβ42 in CSF (r = 0.38, P = 0.0221) and increased levels of p-tau in CSF (r = -0.43, P = 0.0090), findings that have been shown to be associated with AD progression. CONCLUSIONS: This novel method might be very useful for monitoring of the progression of AD.
AIM: Decreased amyloid β (Aβ) clearance from the brain to blood might play a key role in the development of Alzheimer's disease (AD). Aβ is normally bound to and transported by albumin in blood, thus possibly maintaining constant concentration of free Aβ in the blood. We therefore hypothesized that decreased blood levels of albumin-Aβ complexes could be associated with decreased Aβ removal from the brain to blood, resulting in Aβ accumulation in the brain. METHODS: We carried out a cross-sectional investigation of the association between serum levels of albumin-Aβ complexes (SLAAC) and AD prevalence in 89 patients who visited our outpatient clinic, and gave written informed consent between August 2008 and May 2012. RESULTS: We confirmed 45 cases of AD. Low SLAAC was associated with an increased prevalence of AD (OR 0.27; 95% CI 0.14-0.51) in a univariable logistic model and multivariable logistic models. In addition, decreased SLAAC was associated with decreased levels of Aβ42 in CSF (r = 0.38, P = 0.0221) and increased levels of p-tau in CSF (r = -0.43, P = 0.0090), findings that have been shown to be associated with AD progression. CONCLUSIONS: This novel method might be very useful for monitoring of the progression of AD.
Authors: Aparna Nandakumar; Yanting Xing; Ritchlynn R Aranha; Ava Faridi; Aleksandr Kakinen; Ibrahim Javed; Kairi Koppel; Emily H Pilkington; Anthony Wayne Purcell; Thomas P Davis; Pouya Faridi; Feng Ding; Pu Chun Ke Journal: Biomacromolecules Date: 2020-01-21 Impact factor: 6.988