Literature DB >> 24020122

Pharmacokinetic profile of spectinomycin in rats.

D B Madhura1, R Lee, B Meibohm.   

Abstract

Following intravenous (IV) administration, the pharmacokinetics of spectinomycin in rats was found to be on par with its profile in other mammalian species including humans with respect to its overall excretion and half-life at effective concentrations. This study, however, indicates that a small fraction of the spectinomycin dose is retained in peripheral tissues for a prolonged period of time at low concentrations.

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Year:  2013        PMID： 24020122      PMCID： PMC4021579     

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  9 in total

1.  Pharmacokinetics and bioavailability of spectinomycin after i.v., i.m., s.c. and oral administration in broiler chickens.

Authors:  E A Abu-Basha; R Gehring; S J Albwa'neh
Journal:  J Vet Pharmacol Ther       Date:  2007-04       Impact factor: 1.786

2.  In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analog.

Authors:  G E Zurenko; B H Yagi; J J Vavra; B B Wentworth
Journal:  Antimicrob Agents Chemother       Date:  1988-02       Impact factor: 5.191

3.  Serum and milk concentrations of spectinomycin and tylosin in cows and ewes.

Authors:  G Ziv; F G Sulman
Journal:  Am J Vet Res       Date:  1973-03       Impact factor: 1.156

4.  Residues of some veterinary drugs in animals and foods. Monographs prepared by the Forty-second Meeting of the Joint FAO/WHO Expert Committee on Food Additives.

Authors: 
Journal:  FAO Food Nutr Pap       Date:  1994

Review 5.  Physiological parameters in laboratory animals and humans.

Authors:  B Davies; T Morris
Journal:  Pharm Res       Date:  1993-07       Impact factor: 4.200

6.  Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics--I. Biochemical analysis.

Authors:  M P Mingeot-Leclercq; J Piret; R Brasseur; P M Tulkens
Journal:  Biochem Pharmacol       Date:  1990-08-01       Impact factor: 5.858

7.  Human safety and pharmacokinetics of a single intramuscular dose of a novel spectinomycin analog, trospectomycin (U-63,366F).

Authors:  E Novak; L M Paxton; A Bye; R Patel; G E Zurenko; S F Francom
Journal:  Antimicrob Agents Chemother       Date:  1990-12       Impact factor: 5.191

8.  Inhibition of protein synthesis by spectinomycin.

Authors:  J Davies; P Anderson; B D Davis
Journal:  Science       Date:  1965-09-03       Impact factor: 47.728

9.  A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance.

Authors:  Keith W Ward; Brian R Smith
Journal:  Drug Metab Dispos       Date:  2004-06       Impact factor: 3.922
  9 in total
  4 in total

1.  Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.

Authors:  Jiuyu Liu; David F Bruhn; Robin B Lee; Zhong Zheng; Tanja Janusic; Dimitri Scherbakov; Michael S Scherman; Helena I Boshoff; Sourav Das; Samanthi L Waidyarachchi; Tiffany A Brewer; Begoña Gracia; Lei Yang; John Bollinger; Gregory T Robertson; Bernd Meibohm; Anne J Lenaerts; Jose Ainsa; Erik C Böttger; Richard E Lee
Journal:  ACS Infect Dis       Date:  2016-11-11       Impact factor: 5.084

2.  Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.

Authors:  David F Bruhn; Samanthi L Waidyarachchi; Dora B Madhura; Dimitri Shcherbakov; Zhong Zheng; Jiuyu Liu; Yasser M Abdelrahman; Aman P Singh; Stefan Duscha; Chetan Rathi; Robin B Lee; Robert J Belland; Bernd Meibohm; Jason W Rosch; Erik C Böttger; Richard E Lee
Journal:  Sci Transl Med       Date:  2015-05-20       Impact factor: 17.956

3.  Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis.

Authors:  Santosh Wagh; Chetan Rathi; Pradeep B Lukka; Keyur Parmar; Zaid Temrikar; Jiuyu Liu; Michael S Scherman; Richard E Lee; Gregory T Robertson; Anne J Lenaerts; Bernd Meibohm
Journal:  Antimicrob Agents Chemother       Date:  2021-08-23       Impact factor: 5.191

4.  Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.

Authors:  Richard E Lee; Julian G Hurdle; Jiuyu Liu; David F Bruhn; Tanja Matt; Michael S Scherman; Bernd Meibohm; Erik C Böttger; Anne J Lenaerts; Pavan K Vaddady; Zhong Zheng; Jianjun Qi; Rashid Akbergenov; Sourav Das; Dora B Madhura; Chetan Rathi; Ashit Trivedi; Cristina Villellas; Robin B Lee; Samanthi L Waidyarachchi; Dianqing Sun; Michael R McNeil; Jose A Ainsa; Helena I Boshoff; Mercedes Gonzalez-Juarrero
Journal:  Nat Med       Date:  2014-01-26       Impact factor: 53.440
  4 in total

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