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Literature DB >> 24019999

Mitochondrial sirtuins as therapeutic targets for age-related disorders.

Abstract

Sirtuins are a class of histone deacetylases that have a wide range of regulatory roles in the cell. Three sirtuins, SIRT3 to SIRT5, localize to and function within the mitochondria. Mitochondrial dysfunction is thought to be the underlying mechanism of several age-related diseases, such as metabolic syndrome, cancer, and neurodegeneration. This review examines current evidence that mitochondrial sirtuins are involved in regulating mitochondrial function and pathogenesis.

Entities: Disease Gene

Keywords: aging; cancer; metabolic syndrome; mitochondria; neurodegeneration; sirtuins; therapeutic targets

Year: 2013 PMID： 24019999 PMCID： PMC3764472 DOI： 10.1177/1947601912474931

Source DB: PubMed Journal: Genes Cancer ISSN： 1947-6019

63 in total

1. On the origin of cancer cells.

Authors: O WARBURG
Journal: Science Date: 1956-02-24 Impact factor: 47.728

2. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked.

Authors: J Yang; X Liu; K Bhalla; C N Kim; A M Ibrado; J Cai; T I Peng; D P Jones; X Wang
Journal: Science Date: 1997-02-21 Impact factor: 47.728

3. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors: M Kaeberlein; M McVey; L Guarente
Journal: Genes Dev Date: 1999-10-01 Impact factor: 11.361

4. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

Authors: Tadahiro Shimazu; Matthew D Hirschey; Lan Hua; Kristin E Dittenhafer-Reed; Bjoern Schwer; David B Lombard; Yu Li; Jakob Bunkenborg; Frederick W Alt; John M Denu; Matthew P Jacobson; Eric Verdin
Journal: Cell Metab Date: 2010-12-01 Impact factor: 27.287

5. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.

Authors: Qijun Wang; Yakun Zhang; Chen Yang; Hui Xiong; Yan Lin; Jun Yao; Hong Li; Lu Xie; Wei Zhao; Yufeng Yao; Zhi-Bin Ning; Rong Zeng; Yue Xiong; Kun-Liang Guan; Shimin Zhao; Guo-Ping Zhao
Journal: Science Date: 2010-02-19 Impact factor: 47.728

6. SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways.

Authors: Simon J Allison; Jo Milner
Journal: Cell Cycle Date: 2007-08-10 Impact factor: 4.534

7. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.

Authors: Hongying Yang; Tianle Yang; Joseph A Baur; Evelyn Perez; Takashi Matsui; Juan J Carmona; Dudley W Lamming; Nadja C Souza-Pinto; Vilhelm A Bohr; Anthony Rosenzweig; Rafael de Cabo; Anthony A Sauve; David A Sinclair
Journal: Cell Date: 2007-09-21 Impact factor: 41.582

Review 8. Conserved metabolic regulatory functions of sirtuins.

Authors: Bjoern Schwer; Eric Verdin
Journal: Cell Metab Date: 2008-02 Impact factor: 27.287

Review 9. Novel regulation of insulin secretion: the role of mitochondria.

Authors: Pierre Maechler
Journal: Curr Opin Investig Drugs Date: 2003-10

10. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.

Authors: Jintang Du; Yeyun Zhou; Xiaoyang Su; Jiu Jiu Yu; Saba Khan; Hong Jiang; Jungwoo Kim; Jimin Woo; Jun Huyn Kim; Brian Hyun Choi; Bin He; Wei Chen; Sheng Zhang; Richard A Cerione; Johan Auwerx; Quan Hao; Hening Lin
Journal: Science Date: 2011-11-11 Impact factor: 47.728

7 in total

1. Skewed expression of the genes encoding epigenetic modifiers in high-risk uveal melanoma.

Authors: Naoimh Herlihy; Mehmet Dogrusöz; T Huibertus van Essen; J William Harbour; Pieter A van der Velden; Marja C J A van Eggermond; Geert W Haasnoot; Peter J van den Elsen; Martine J Jager
Journal: Invest Ophthalmol Vis Sci Date: 2015-01-15 Impact factor: 4.799

Mitochondrial sirtuins as therapeutic targets for age-related disorders.

1. On the origin of cancer cells.

2. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked.

3. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

4. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

5. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.

6. SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways.

7. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.

Review 8. Conserved metabolic regulatory functions of sirtuins.

Review 9. Novel regulation of insulin secretion: the role of mitochondria.

10. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.

1. Skewed expression of the genes encoding epigenetic modifiers in high-risk uveal melanoma.

Review 2. Mitochondrial Sirtuins in Cancer: Emerging Roles and Therapeutic Potential.

3. Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.

4. Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson's disease.

Review 5. SIRTain regulators of premature senescence and accelerated aging.

6. The role of sirtuins in Alzheimer's disease.

Review 7. The therapeutic potential of epigenetic manipulation during infectious diseases.