OBJECTIVE: To describe the angiotensin converting enzyme (ACE) genotype frequencies among Omani Arabs. METHOD: A polymerase chain reaction (PCR) test, based on separation of different size DNA fragments, was developed to test the presence or absence (polymorphism) of a small DNA deletion in the ACE gene. The subjects were 124 Omani Arab students of Sultan Qaboos University, Muscat. RESULTS: The frequency of the I allele was 0.29, while that of the D allele was 0.71. The gene frequency distribution did not deviate from Hardy-Weinberg equilibrium. CONCLUSIONS: The frequency of D allele among Omanis is similar to that among other Arabs and Africans, but differs significantly from that among the Japanese and Chinese.
OBJECTIVE: To describe the angiotensin converting enzyme (ACE) genotype frequencies among Omani Arabs. METHOD: A polymerase chain reaction (PCR) test, based on separation of different size DNA fragments, was developed to test the presence or absence (polymorphism) of a small DNA deletion in the ACE gene. The subjects were 124 Omani Arab students of Sultan Qaboos University, Muscat. RESULTS: The frequency of the I allele was 0.29, while that of the D allele was 0.71. The gene frequency distribution did not deviate from Hardy-Weinberg equilibrium. CONCLUSIONS: The frequency of D allele among Omanis is similar to that among other Arabs and Africans, but differs significantly from that among the Japanese and Chinese.
Authors: K Kario; N Kanai; S Nishiuma; T Fujii; K Saito; T Matsuo; M Matsuo; K Shimada Journal: Arterioscler Thromb Vasc Biol Date: 1997-02 Impact factor: 8.311
Authors: M V Raynolds; M R Bristow; E W Bush; W T Abraham; B D Lowes; L S Zisman; C S Taft; M B Perryman Journal: Lancet Date: 1993-10-30 Impact factor: 79.321
Authors: J Barley; A Blackwood; N D Carter; D E Crews; J K Cruickshank; S Jeffery; A O Ogunlesi; G A Sagnella Journal: J Hypertens Date: 1994-08 Impact factor: 4.844
Authors: S MacMahon; R Peto; J Cutler; R Collins; P Sorlie; J Neaton; R Abbott; J Godwin; A Dyer; J Stamler Journal: Lancet Date: 1990-03-31 Impact factor: 79.321