| Literature DB >> 24018959 |
Elmira Mikaeili Agah1, Kazem Parivar, Mohammad Nabiuni, Mehrdad Hashemi, Masoud Soleimani.
Abstract
In this study, we examined phenotypic features of human Wharton's jelly mesenchymal stem cells-derived oligodendrocytes. We induced human WJMSCs to form OLs by signaling molecules including basic fibroblastic growth factor, platelet-derived growth factor-AA, and triiodothyronine hormone. Differentiated WJMSCs showed morphologic characteristics of an OL phenotype. Expression of surface markers and genes in oligodendrocyte precursor cells or OLs were analyzed by immunocytochemistry staining and real-time polymerase chain reaction, respectively. These results suggest that WJMSCs could be programmed to OLs and might provide a potential source for cell therapy in neurodegenerative disease.Entities:
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Year: 2013 PMID： 24018959 DOI： 10.1007/s12031-013-0094-5
Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444