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Literature DB >> 24018422

The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair.

Alexander J Garvin¹, Ruth M Densham, Sarah A Blair-Reid, Kenny M Pratt, Helen R Stone, Daniel Weekes, Kirsty J Lawrence, Joanna R Morris.

Abstract

SUMO conjugation is known to occur in response to double-stranded DNA breaks in mammalian cells, but whether SUMO deconjugation has a role remains unclear. Here, we show that the SUMO/Sentrin/Smt3-specific peptidase, SENP7, interacts with the chromatin repressive KRAB-associated protein 1 (KAP1) through heterochromatin protein 1 alpha (HP1α). SENP7 promotes the removal of SUMO2/3 from KAP1 and regulates the interaction of the chromatin remodeler CHD3 with chromatin. Consequently, in the presence of CHD3, SENP7 is required for chromatin relaxation in response to DNA damage, for homologous recombination repair and for cellular resistance to DNA-damaging agents. Thus, deSUMOylation by SENP7 is required to promote a permissive chromatin environment for DNA repair.

Entities: Chemical

Mesh：

Substances：

Year: 2013 PMID： 24018422 PMCID： PMC3818072 DOI： 10.1038/embor.2013.141

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

28 in total

Review 1. Mi-2/NuRD: multiple complexes for many purposes.

Authors: Nathan J Bowen; Naoyuki Fujita; Masahiro Kajita; Paul A Wade
Journal: Biochim Biophys Acta Date: 2004-03-15

2. KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions.

Authors: David E White; Dmitri Negorev; Hongzhuang Peng; Alexey V Ivanov; Gerd G Maul; Frank J Rauscher
Journal: Cancer Res Date: 2006-12-15 Impact factor: 12.701

3. Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7.

Authors: Kamela O Alegre; David Reverter
Journal: J Biol Chem Date: 2011-08-30 Impact factor: 5.157

4. Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair.

Authors: Ivan Psakhye; Stefan Jentsch
Journal: Cell Date: 2012-11-01 Impact factor: 41.582

5. DeSUMOylating isopeptidase: a second class of SUMO protease.

Authors: Eun Ju Shin; Hyun Mi Shin; Eori Nam; Won Seog Kim; Ji-Hoon Kim; Byung-Ha Oh; Yungdae Yun
Journal: EMBO Rep Date: 2012-04 Impact factor: 8.807

6. Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.

Authors: Hong Dou; Chao Huang; Melissa Singh; Phillip B Carpenter; Edward T H Yeh
Journal: Mol Cell Date: 2010-08-13 Impact factor: 17.970

7. The impact of heterochromatin on DSB repair.

Authors: Aaron A Goodarzi; Angela T Noon; Penny A Jeggo
Journal: Biochem Soc Trans Date: 2009-06 Impact factor: 5.407

8. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.

Authors: Jian Ouyang; Yujiang Shi; Alvaro Valin; Yan Xuan; Grace Gill
Journal: Mol Cell Date: 2009-04-24 Impact factor: 17.970

Review 9. KAP1 protein: an enigmatic master regulator of the genome.

Authors: Sushma Iyengar; Peggy J Farnham
Journal: J Biol Chem Date: 2011-06-07 Impact factor: 5.157

10. The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks.

Authors: Céline Courilleau; Catherine Chailleux; Alain Jauneau; Fanny Grimal; Sébastien Briois; Elisa Boutet-Robinet; François Boudsocq; Didier Trouche; Yvan Canitrot
Journal: J Cell Biol Date: 2012-12-24 Impact factor: 10.539

34 in total

Review 1. Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers.

Authors: Petra Schwertman; Simon Bekker-Jensen; Niels Mailand
Journal: Nat Rev Mol Cell Biol Date: 2016-05-23 Impact factor: 94.444

2. An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.

Authors: Ching-Ying Kuo; Xu Li; Xiang-Qian Kong; Cheng Luo; Che-Chang Chang; Yiyin Chung; Hsiu-Ming Shih; Keqin Kathy Li; David K Ann
Journal: J Biol Chem Date: 2014-06-06 Impact factor: 5.157

Review 3. Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics.

Authors: Brian L Lee; Anamika Singh; J N Mark Glover; Michael J Hendzel; Leo Spyracopoulos
Journal: J Mol Biol Date: 2017-06-03 Impact factor: 5.469

The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair.

Review 1. Mi-2/NuRD: multiple complexes for many purposes.

2. KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions.

3. Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7.

4. Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair.

5. DeSUMOylating isopeptidase: a second class of SUMO protease.

6. Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.

7. The impact of heterochromatin on DSB repair.

8. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.

Review 9. KAP1 protein: an enigmatic master regulator of the genome.

10. The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks.

Review 1. Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers.

2. An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.

Review 3. Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics.

4. SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase.

Review 5. KAPtain in charge of multiple missions: Emerging roles of KAP1.

Review 6. SENP Proteases as Potential Targets for Cancer Therapy.

7. KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair.

Review 8. Post-Translational Modifications in Oocyte Maturation and Embryo Development.

9. Epigenetic repression of herpes simplex virus infection by the nucleosome remodeler CHD3.

Review 10. SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer.