BACKGROUND: During the past 10 years, chronic kidney disease (CKD) has been recognized as a major global health problem. Factors leading to decreased renal function are closely related to cardiovascular disease and vice versa. Cardiovascular morbidity and mortality are substantially increased in patients with CKD, even in those with only mild or moderate renal impairment. A better understanding of pathogenesis, risk factors, and genetic conditions is strongly required for more specific treatment strategies in CKD because until now, knowledge is very limited. METHODS: The German CAD-REF registry is a prospective observational multicenter national registry. It aims at including >3,300 white patients with angiographically documented coronary artery disease (coronary artery disease [CAD]; ≥50% stenosis in at least 1 coronary artery) being enrolled at 32 centers and assigned to 6 different groups according to their estimated glomerular filtration rate and/or proteinuria. Baseline characteristics, treatment data, and biomaterial including serum, plasma, urine, and DNA samples are collected. Follow-ups are performed at 6, 12, 24, 36, 48, and 60 months. CONCLUSIONS: The CAD-REF registry will establish one of the largest ethnically homogeneous cohorts, to date, of clinically and angiographically well-characterized patients with CAD who have all stages of CKD. This approach offers great opportunities for an improved understanding of the underlying pathophysiologic mechanism and clinical impact of CKD in patients with CAD, especially including the identification of clinically relevant risk factors and (genetic and other bio-) markers as a basis to ameliorate future treatment strategies.
BACKGROUND: During the past 10 years, chronic kidney disease (CKD) has been recognized as a major global health problem. Factors leading to decreased renal function are closely related to cardiovascular disease and vice versa. Cardiovascular morbidity and mortality are substantially increased in patients with CKD, even in those with only mild or moderate renal impairment. A better understanding of pathogenesis, risk factors, and genetic conditions is strongly required for more specific treatment strategies in CKD because until now, knowledge is very limited. METHODS: The German CAD-REF registry is a prospective observational multicenter national registry. It aims at including >3,300 white patients with angiographically documented coronary artery disease (coronary artery disease [CAD]; ≥50% stenosis in at least 1 coronary artery) being enrolled at 32 centers and assigned to 6 different groups according to their estimated glomerular filtration rate and/or proteinuria. Baseline characteristics, treatment data, and biomaterial including serum, plasma, urine, and DNA samples are collected. Follow-ups are performed at 6, 12, 24, 36, 48, and 60 months. CONCLUSIONS: The CAD-REF registry will establish one of the largest ethnically homogeneous cohorts, to date, of clinically and angiographically well-characterized patients with CAD who have all stages of CKD. This approach offers great opportunities for an improved understanding of the underlying pathophysiologic mechanism and clinical impact of CKD in patients with CAD, especially including the identification of clinically relevant risk factors and (genetic and other bio-) markers as a basis to ameliorate future treatment strategies.
Authors: Holger Reinecke; Günter Breithardt; Christiane Engelbertz; Roland E Schmieder; Manfred Fobker; Hans O Pinnschmidt; Boris Schmitz; Philipp Bruland; Karl Wegscheider; Hermann Pavenstädt; Eva Brand Journal: PLoS One Date: 2016-02-09 Impact factor: 3.240
Authors: Boris Schmitz; Marcus E Kleber; Malte Lenders; Graciela E Delgado; Christiane Engelbertz; Jie Huang; Hermann Pavenstädt; Günter Breithardt; Stefan-Martin Brand; Winfried März; Eva Brand Journal: Sci Rep Date: 2019-02-26 Impact factor: 4.379
Authors: Susanne Stolpe; Bernd Kowall; Christian Scholz; Andreas Stang; Cornelia Blume Journal: Int J Environ Res Public Health Date: 2021-11-09 Impact factor: 3.390
Authors: Christiane Engelbertz; Hans O Pinnschmidt; Eva Freisinger; Holger Reinecke; Boris Schmitz; Manfred Fobker; Roland E Schmieder; Karl Wegscheider; Günter Breithardt; Hermann Pavenstädt; Eva Brand Journal: Clin Res Cardiol Date: 2021-05-26 Impact factor: 5.460