BACKGROUND: The effects of both high and low levels of testosterone are wide ranging and can include changes in mood, often overlapping with symptoms of mood disorders. OBJECTIVE: We sought to review the literature on the correlation of high and low levels of testosterone on mood disorders in men. RESULTS: Based on limited studies, high levels of testosterone are related to increased rates of depression as well as hypomania, whereas low levels of testosterone are related to depressive disorders in certain subpopulations of patients. There is insufficient evidence to conclude that low testosterone level routinely leads to major depressive disorder in men. CONCLUSIONS: Physicians should consider screening for low testosterone levels in certain subgroups of depressed men.
BACKGROUND: The effects of both high and low levels of testosterone are wide ranging and can include changes in mood, often overlapping with symptoms of mood disorders. OBJECTIVE: We sought to review the literature on the correlation of high and low levels of testosterone on mood disorders in men. RESULTS: Based on limited studies, high levels of testosterone are related to increased rates of depression as well as hypomania, whereas low levels of testosterone are related to depressive disorders in certain subpopulations of patients. There is insufficient evidence to conclude that low testosterone level routinely leads to major depressive disorder in men. CONCLUSIONS: Physicians should consider screening for low testosterone levels in certain subgroups of depressed men.
Authors: Jennifer B Dwyer; Awais Aftab; Rajiv Radhakrishnan; Alik Widge; Carolyn I Rodriguez; Linda L Carpenter; Charles B Nemeroff; William M McDonald; Ned H Kalin Journal: Am J Psychiatry Date: 2020-05-27 Impact factor: 18.112
Authors: Ilmari Määttänen; Kia Gluschkoff; Kaisla Komulainen; Jaakko Airaksinen; Kateryna Savelieva; Regina García-Velázquez; Markus Jokela Journal: Compr Psychoneuroendocrinol Date: 2021-03-10
Authors: Sarah L Kerns; Chunkit Fung; Patrick O Monahan; Shirin Ardeshir-Rouhani-Fard; Mohammad I Abu Zaid; AnnaLynn M Williams; Timothy E Stump; Howard D Sesso; Darren R Feldman; Robert J Hamilton; David J Vaughn; Clair Beard; Robert A Huddart; Jeri Kim; Christian Kollmannsberger; Deepak M Sahasrabudhe; Ryan Cook; Sophie D Fossa; Lawrence H Einhorn; Lois B Travis Journal: J Clin Oncol Date: 2018-04-04 Impact factor: 44.544
Authors: Stephanie Rodgers; Martin Grosse Holtforth; Michael P Hengartner; Mario Müller; Aleksandra A Aleksandrowicz; Wulf Rössler; Vladeta Ajdacic-Gross Journal: Front Psychiatry Date: 2015-05-04 Impact factor: 4.157