Literature DB >> 24014346

Characterisation of CMP-sialic acid transporter substrate recognition.

Andrea Maggioni1, Mark von Itzstein, Ingrid Bibiana Rodríguez Guzmán, Angel Ashikov, Alexandre S Stephens, Thomas Haselhorst, Joe Tiralongo.   

Abstract

CMP-sialic acid transporter: We report an in-depth, multidisciplinary, structural study that has identified the amino acid residues intimately involved in CMP-sialic acid transporter (CST) substrate specificity. Our data provide a significant contribution towards a better understanding the structure-function relationship of this important family of transporters and the rational design of CST inhibitors.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  CMP-sialic acid transporter; NMR spectroscopy; nucleotide sugar transporters; sialic acids; site-directed mutagenesis

Mesh：

Substances：

Year:  2013        PMID： 24014346     DOI： 10.1002/cbic.201300298

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  5 in total

1.  Conserved Glu-47 and Lys-50 residues are critical for UDP-N-acetylglucosamine/UMP antiport activity of the mouse Golgi-associated transporter Slc35a3.

Authors:  M Agustina Toscanini; M Belén Favarolo; F Luis Gonzalez Flecha; Berit Ebert; Carsten Rautengarten; Luis M Bredeston
Journal:  J Biol Chem       Date:  2019-05-22       Impact factor: 5.157

2.  A functional splice variant of the human Golgi CMP-sialic acid transporter.

Authors:  Roberta Salinas-Marín; Rosella Mollicone; Iván Martínez-Duncker
Journal:  Glycoconj J       Date:  2016-07-07       Impact factor: 2.916

3.  Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy.

Authors:  Paul D Madge; Andrea Maggioni; Mauro Pascolutti; Moein Amin; Mario Waespy; Bernadette Bellette; Robin J Thomson; Sørge Kelm; Mark von Itzstein; Thomas Haselhorst
Journal:  Sci Rep       Date:  2016-11-03       Impact factor: 4.379

Review 4.  Nucleotide Sugar Transporter SLC35 Family Structure and Function.

Authors:  Barbara Hadley; Thomas Litfin; Chris J Day; Thomas Haselhorst; Yaoqi Zhou; Joe Tiralongo
Journal:  Comput Struct Biotechnol J       Date:  2019-08-07       Impact factor: 7.271

Review 5.  Structure and function of nucleotide sugar transporters: Current progress.

Authors:  Barbara Hadley; Andrea Maggioni; Angel Ashikov; Christopher J Day; Thomas Haselhorst; Joe Tiralongo
Journal:  Comput Struct Biotechnol J       Date:  2014-06-11       Impact factor: 7.271
  5 in total

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