Literature DB >> 24014051

Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis.

Shahab Uddin1, Azhar R Hussain, Omar S Khan, Khawla S Al-Kuraya.   

Abstract

Leptin is a multifunctional adipose-derived cytokine that plays a critical role in bodyweight homeostasis and energy balance. Plasma level of leptin is an indicator of the amount of energy stored in adipose tissues. Recently, leptin and leptin receptor dysregulation have been reported in a variety of malignant cells including colorectal cancers (CRCs). There are growing evidence that leptin may be the link between obesity and CRC carcinogenesis. Leptin influence the growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT, and/or MAP kinases. In this review, current understanding of leptin and its receptor's roles in the pathogenesis of colonogenic cancer has been described.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 24014051     DOI： 10.1007/s13277-013-1166-4

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  90 in total

Review 1.  Medical consequences of obesity.

Authors:  George A Bray
Journal:  J Clin Endocrinol Metab       Date:  2004-06       Impact factor: 5.958

2.  Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro.

Authors:  Sadahiro Amemori; Akifumi Ootani; Shigehisa Aoki; Takehiro Fujise; Ryo Shimoda; Takashi Kakimoto; Ryosuke Shiraishi; Yasuhisa Sakata; Seji Tsunada; Ryuichi Iwakiri; Kazuma Fujimoto
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2007-03       Impact factor: 4.052

3.  Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.

Authors:  H C Chen; J L Guan
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-11       Impact factor: 11.205

4.  Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention.

Authors:  Chinthalapally V Rao; Naveena B Janakiram; Altaf Mohammed
Journal:  Curr Colorectal Cancer Rep       Date:  2012-12

5.  Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010.

Authors:  Cynthia L Ogden; Margaret D Carroll; Brian K Kit; Katherine M Flegal
Journal:  JAMA       Date:  2012-01-17       Impact factor: 56.272

6.  Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase.

Authors:  G R van den Brink; T O'Toole; J C Hardwick; D E van den Boogaardt; H H Versteeg; S J van Deventer; M P Peppelenbosch
Journal:  Mol Cell Biol Res Commun       Date:  2000-09

Review 7.  Obesity and cancer--the update 2013.

Authors:  Heiner Boeing
Journal:  Best Pract Res Clin Endocrinol Metab       Date:  2013-05-15       Impact factor: 4.690

8.  Positional cloning of the mouse obese gene and its human homologue.

Authors:  Y Zhang; R Proenca; M Maffei; M Barone; L Leopold; J M Friedman
Journal:  Nature       Date:  1994-12-01       Impact factor: 49.962

Review 9.  Leptin receptors.

Authors:  Elzbieta Gorska; K Popko; A Stelmaszczyk-Emmel; O Ciepiela; A Kucharska; M Wasik
Journal:  Eur J Med Res       Date:  2010-11-04       Impact factor: 2.175

10.  Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells.

Authors:  Neeraj K Saxena; Dipali Sharma; Xiaokun Ding; Songbai Lin; Fabio Marra; Didier Merlin; Frank A Anania
Journal:  Cancer Res       Date:  2007-03-15       Impact factor: 12.701
View more
  8 in total

1.  No significant association between PIK3CA mutation and survival of esophageal squamous cell carcinoma: A meta-analysis.

Authors:  Xiao-Qing Ge; Yan-Zheng Yang; Sha-Sha Li; Lu Hou; Jing-Li Ren; Kun-Peng Yang; Xian-En Fa
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2017-06-06

Review 2.  Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers.

Authors:  Qiang Chen; Kesong Peng; Pingli Mo; Chundong Yu
Journal:  Cancers (Basel)       Date:  2022-06-08       Impact factor: 6.575

Review 3.  Obesity and cancer pathogenesis.

Authors:  Nathan A Berger
Journal:  Ann N Y Acad Sci       Date:  2014-04       Impact factor: 5.691

4.  Correlation of leptin receptor expression with BMI in differential grades of human meningiomas.

Authors:  Robert Rutkowski; Joanna Reszec; Adam Hermanowicz; Robert Chrzanowski; Tomasz Lyson; Zenon Mariak; Lech Chyczewski
Journal:  Oncol Lett       Date:  2016-02-24       Impact factor: 2.967

5.  Protracted upregulation of leptin and IGF1 is associated with activation of PI3K/Akt and JAK2 pathway in mouse intestine after ionizing radiation exposure.

Authors:  Shubhankar Suman; Bhaskar V S Kallakury; Albert J Fornace; Kamal Datta
Journal:  Int J Biol Sci       Date:  2015-01-20       Impact factor: 6.580

6.  Leptin and adiponectin dynamics at patients with rectal neoplasm - Gender differences.

Authors:  Alexandru Florescu; Dumitru Branisteanu; Stefana Bilha; Dragos Scripcariu; Ioana Florescu; Viorel Scripcariu; Gabriel Dimofte; Ioana Grigoras
Journal:  PLoS One       Date:  2019-08-19       Impact factor: 3.240

Review 7.  Epidemiological transition of colorectal cancer in developing countries: environmental factors, molecular pathways, and opportunities for prevention.

Authors:  Faraz Bishehsari; Mahboobeh Mahdavinia; Michele Vacca; Reza Malekzadeh; Renato Mariani-Costantini
Journal:  World J Gastroenterol       Date:  2014-05-28       Impact factor: 5.742

8.  Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation.

Authors:  Ha Thi Ngo; Ragna Bogen Hetland; Unni Cecilie Nygaard; Inger-Lise Steffensen
Journal:  J Obes       Date:  2015-08-10
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.