Literature DB >> 24013873

Transgenic Rat Models of Huntington's Disease.

João Casaca Carreira1, Ali Jahanshahi, Dagmar Zeef, Ersoy Kocabicak, Rinske Vlamings, Stephan von Hörsten, Yasin Temel.   

Abstract

Several animal models for Huntington's disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.

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Year:  2015        PMID： 24013873     DOI： 10.1007/7854_2013_245

Source DB:  PubMed          Journal:  Curr Top Behav Neurosci        ISSN： 1866-3370


  5 in total

1.  Coexistence of Gait Disturbances and Chorea in Experimental Huntington's Disease.

Authors:  João Casaca-Carreira; Yasin Temel; Marloes van Zelst; Ali Jahanshahi
Journal:  Behav Neurol       Date:  2015-05-06       Impact factor: 3.342

2.  Early Alterations in Operant Performance and Prominent Huntingtin Aggregation in a Congenic F344 Rat Line of the Classical CAGn51trunc Model of Huntington Disease.

Authors:  Anne-Christine Plank; Fabio Canneva; Kerstin A Raber; Yvonne K Urbach; Julia Dobner; Maja Puchades; Jan G Bjaalie; Clarissa Gillmann; Tobias Bäuerle; Olaf Riess; Hoa H P Nguyen; Stephan von Hörsten
Journal:  Front Neurosci       Date:  2018-01-25       Impact factor: 4.677

3.  Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease.

Authors:  Erik Karl Håkan Clemensson; Laura Emily Clemensson; Benedikt Fabry; Stefanie Flunkert; Olaf Riess; Robert Wronski; Huu Phuc Nguyen
Journal:  PLoS One       Date:  2017-03-08       Impact factor: 3.240

Review 4.  The Application of Adeno-Associated Viral Vector Gene Therapy to the Treatment of Fragile X Syndrome.

Authors:  David R Hampson; Alexander W M Hooper; Yosuke Niibori
Journal:  Brain Sci       Date:  2019-02-02

5.  Development of in-vitro maturation protocol for rat oocytes; under simple culture vs co-culture with cumulus cell monolayer and its developmental potential via Parthenogenetic/artificial activation.

Authors:  Muhammad Joan Ailia; Yun-Kyong Jin; Hee-Kyoung Kim; Goo Jang
Journal:  BMC Vet Res       Date:  2021-01-22       Impact factor: 2.741
  5 in total

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