OBJECTIVE: Brain donation and neuropathological examination of brain tissues is the only way to obtain definitive diagnostic information on research subjects enrolled in aging studies. We investigated predictors of brain donation in a population-based study of centenarians in Phase III of the Georgia Centenarian Study (GCS). METHODS: Sixty-six individuals (mean age = 100.6 years, 91% female, 20% African American) were successfully recruited from the core sample of 244 individuals residing in 44 counties of Northeast Georgia to provide brain donation. RESULTS: Bivariate (t-tests, chi-square tests) and multivariate analyses (logistic regression) showed no significant differences between donors and non-donors across a wide range of demographic, religious, personality, cognitive and physical functioning characteristics. CONCLUSIONS: We succeeded in recruiting a diverse, population-based sample of centenarians for brain donation. Our findings also suggest that barriers to brain donation reported in other studies may have less impact in these exceptional survivors.
OBJECTIVE: Brain donation and neuropathological examination of brain tissues is the only way to obtain definitive diagnostic information on research subjects enrolled in aging studies. We investigated predictors of brain donation in a population-based study of centenarians in Phase III of the Georgia Centenarian Study (GCS). METHODS: Sixty-six individuals (mean age = 100.6 years, 91% female, 20% African American) were successfully recruited from the core sample of 244 individuals residing in 44 counties of Northeast Georgia to provide brain donation. RESULTS: Bivariate (t-tests, chi-square tests) and multivariate analyses (logistic regression) showed no significant differences between donors and non-donors across a wide range of demographic, religious, personality, cognitive and physical functioning characteristics. CONCLUSIONS: We succeeded in recruiting a diverse, population-based sample of centenarians for brain donation. Our findings also suggest that barriers to brain donation reported in other studies may have less impact in these exceptional survivors.
Authors: Leonard W Poon; Michal Jazwinski; Robert C Green; John L Woodard; Peter Martin; Willard L Rodgers; Mary Ann Johnson; Dorothy Hausman; Jonathan Arnold; Adam Davey; Mark A Batzer; William R Markesbery; Maria Gearing; Ilene C Siegler; Sandra Reynolds; Jianliang Dai Journal: Annu Rev Gerontol Geriatr Date: 2007-01-01
Authors: M J Chandler; L H Lacritz; L S Hynan; H D Barnard; G Allen; M Deschner; M F Weiner; C M Cullum Journal: Neurology Date: 2005-07-12 Impact factor: 9.910
Authors: Jonathan Arnold; Jianliang Dai; Lusine Nahapetyan; Ankit Arte; Mary Ann Johnson; Dorothy Hausman; Willard L Rodgers; Robert Hensley; Peter Martin; Maurice Macdonald; Adam Davey; Ilene C Siegler; S Michal Jazwinski; Leonard W Poon Journal: Curr Gerontol Geriatr Res Date: 2010-09-14
Authors: Janna H Neltner; Erin L Abner; Gregory A Jicha; Frederick A Schmitt; Ela Patel; Leonard W Poon; Gearing Marla; Robert C Green; Adam Davey; Mary Ann Johnson; S Michal Jazwinski; Sangkyu Kim; Daron Davis; John L Woodard; Richard J Kryscio; Linda J Van Eldik; Peter T Nelson Journal: Neurobiol Aging Date: 2015-10-19 Impact factor: 4.673
Authors: Jirayu Tanprasertsuk; Tammy M Scott; Aron K Barbey; Kathryn Barger; Xiang-Dong Wang; Mary Ann Johnson; Leonard W Poon; Rohini Vishwanathan; Nirupa R Matthan; Alice H Lichtenstein; Guylaine Ferland; Elizabeth J Johnson Journal: Front Nutr Date: 2021-06-29
Authors: Elizabeth J Johnson; Rohini Vishwanathan; Mary Ann Johnson; Dorothy B Hausman; Adam Davey; Tammy M Scott; Robert C Green; L Stephen Miller; Marla Gearing; John Woodard; Peter T Nelson; Hae-Yun Chung; Wolfgang Schalch; Jonas Wittwer; Leonard W Poon Journal: J Aging Res Date: 2013-06-09