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Literature DB >> 24013744

Forever (FGF) 21.

Abstract

The fibroblast growth factor 21 (FGF21)-β-Klotho pathway orchestrates a switch to oxidative metabolism during fasting and starvation and has been implicated as a signal connecting nutrition, growth, reproduction and longevity. Two new studies in mice show that Fgf21 interacts directly with the brain circadian clock to coordinate activity and reproduction as part of the adaptation to fasting.

Entities: Gene Species

Mesh：

Substances：

Year: 2013 PMID： 24013744 DOI： 10.1038/nm.3334

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

15 in total

Review 1. SCN outputs and the hypothalamic balance of life.

Authors: A Kalsbeek; I F Palm; S E La Fleur; F A J L Scheer; S Perreau-Lenz; M Ruiter; F Kreier; C Cailotto; R M Buijs
Journal: J Biol Rhythms Date: 2006-12 Impact factor: 3.182

Review 2. Regulation of circadian gene expression in liver by systemic signals and hepatocyte oscillators.

Authors: B Kornmann; O Schaad; H Reinke; C Saini; U Schibler
Journal: Cold Spring Harb Symp Quant Biol Date: 2007

3. Resonating circadian clocks enhance fitness in cyanobacteria.

Authors: Y Ouyang; C R Andersson; T Kondo; S S Golden; C H Johnson
Journal: Proc Natl Acad Sci U S A Date: 1998-07-21 Impact factor: 11.205

4. Resetting central and peripheral circadian oscillators in transgenic rats.

Authors: S Yamazaki; R Numano; M Abe; A Hida; R Takahashi; M Ueda; G D Block; Y Sakaki; M Menaker; H Tei
Journal: Science Date: 2000-04-28 Impact factor: 47.728

5. BetaKlotho is required for metabolic activity of fibroblast growth factor 21.

Authors: Yasushi Ogawa; Hiroshi Kurosu; Masaya Yamamoto; Animesh Nandi; Kevin P Rosenblatt; Regina Goetz; Anna V Eliseenkova; Moosa Mohammadi; Makoto Kuro-o
Journal: Proc Natl Acad Sci U S A Date: 2007-04-23 Impact factor: 11.205

6. Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity.

Authors: Alan Gerber; Cyril Esnault; Gregory Aubert; Richard Treisman; François Pralong; Ueli Schibler
Journal: Cell Date: 2013-01-31 Impact factor: 41.582

7. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.

Authors: Michael K Badman; Pavlos Pissios; Adam R Kennedy; George Koukos; Jeffrey S Flier; Eleftheria Maratos-Flier
Journal: Cell Metab Date: 2007-06 Impact factor: 27.287

8. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.

Authors: Yuan Zhang; Yang Xie; Eric D Berglund; Katie Colbert Coate; Tian Teng He; Takeshi Katafuchi; Guanghua Xiao; Matthew J Potthoff; Wei Wei; Yihong Wan; Ruth T Yu; Ronald M Evans; Steven A Kliewer; David J Mangelsdorf
Journal: Elife Date: 2012-10-15 Impact factor: 8.140

9. FGF21 regulates metabolism and circadian behavior by acting on the nervous system.

Authors: Angie L Bookout; Marleen H M de Groot; Bryn M Owen; Syann Lee; Laurent Gautron; Heather L Lawrence; Xunshan Ding; Joel K Elmquist; Joseph S Takahashi; David J Mangelsdorf; Steven A Kliewer
Journal: Nat Med Date: 2013-08-11 Impact factor: 53.440