| Literature DB >> 24013411 |
Shadia A Galal1, Ahmed S Abdelsamie, Salwa M Soliman, Jeremie Mortier, Gerhard Wolber, Mamdouh M Ali, Harukuni Tokuda, Nobutaka Suzuki, Akira Lida, Raghda A Ramadan, Hoda I El Diwani.
Abstract
The cancer chemopreventive activity of quinoxaline derivatives 1-20 has been evaluated by studying the inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) activation. The quinoxaline derivatives 1-20 showed inhibitory effect on EBV-EA activation without cytotoxicity on Raji cells. All compounds exhibited dose dependent inhibitory activities, most of them showed significant activity at 1000 mol ratio/12-O-tetradecanoylphorbol-13-acetate (TPA). Compounds 7 and 9 exhibited stronger inhibitory effects on the EBV-EA activation than that of the representative control, oleanolic acid, at the highest measured concentration. In addition, compounds 7-10 showed potent and selective inhibition of human tyrosine kinase (TRK) in liver cancer HepG2 and breast cancer MCF-7 cell lines similar to the positive control, doxorubicin.Entities:
Keywords: Cancer chemopreventive activity; Docking; Epstein–Barr virus; Protein tyrosine kinase; Quinoxalines; Synthesis
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Year: 2013 PMID： 24013411 DOI： 10.1016/j.ejmech.2013.07.049
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514