Literature DB >> 24012393

Targeting the PI3-kinase/Akt/mTOR signaling pathway.

Burhan Hassan1, Argun Akcakanat, Ashley M Holder, Funda Meric-Bernstam.   

Abstract

This article presents an overview of the PI3K/Akt/mTOR signaling pathway. As a central regulator of cell growth, protein translation, survival, and metabolism, activation of this signaling pathway contributes to the pathogenesis of many tumor types. Biochemical and genetic aberrations of this pathway observed in various cancer types are explored. Last, pathway inhibitors both in development and already approved by the Food and Drug Administration are discussed.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cell signaling; Molecular targeted therapy; PI3K/Akt/mTOR signaling pathway; PTEN

Mesh：

Substances：

Year:  2013        PMID： 24012393      PMCID： PMC3811932          DOI： 10.1016/j.soc.2013.06.008

Source DB:  PubMed          Journal:  Surg Oncol Clin N Am        ISSN： 1055-3207            Impact factor:   3.495


  205 in total

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4.  NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling.

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7.  The PIK3CA gene is mutated with high frequency in human breast cancers.

Authors:  Kurtis E Bachman; Pedram Argani; Yardena Samuels; Natalie Silliman; Janine Ptak; Steve Szabo; Hiroyuki Konishi; Bedri Karakas; Brian G Blair; Clarence Lin; Brock A Peters; Victor E Velculescu; Ben Ho Park
Journal:  Cancer Biol Ther       Date:  2004-08-26       Impact factor: 4.742

8.  Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.

Authors:  Estela Jacinto; Robbie Loewith; Anja Schmidt; Shuo Lin; Markus A Rüegg; Alan Hall; Michael N Hall
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9.  Oncogenic mutations of PIK3CA in human cancers.

Authors:  Yardena Samuels; Victor E Velculescu
Journal:  Cell Cycle       Date:  2004-10-12       Impact factor: 4.534

10.  Somatic mutation of PTEN in bladder carcinoma.

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2.  DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress.

Authors:  Bridget Simonson; Vinita Subramanya; Mun Chun Chan; Aifeng Zhang; Hannabeth Franchino; Filomena Ottaviano; Manoj K Mishra; Ashley C Knight; Danielle Hunt; Ionita Ghiran; Tejvir S Khurana; Maria I Kontaridis; Anthony Rosenzweig; Saumya Das
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3.  Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway.

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Review 4.  Neurodegenerative diseases: model organisms, pathology and autophagy.

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5.  Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with AKT1 E17K-Mutant, ER-Positive Metastatic Breast Cancer.

Authors:  Lillian M Smyth; Kenji Tamura; Mafalda Oliveira; Eva M Ciruelos; Ingrid A Mayer; Marie-Paule Sablin; Laura Biganzoli; Helen J Ambrose; Jack Ashton; Alan Barnicle; Des D Cashell; Claire Corcoran; Elza C de Bruin; Andrew Foxley; Joana Hauser; Justin P O Lindemann; Rhiannon Maudsley; Robert McEwen; Michele Moschetta; Martin Pass; Vicky Rowlands; Gaia Schiavon; Udai Banerji; Maurizio Scaltriti; Barry S Taylor; Sarat Chandarlapaty; José Baselga; David M Hyman
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6.  Mst1 regulates glioma cell proliferation via the AKT/mTOR signaling pathway.

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Review 7.  The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.

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Review 8.  Conventional chemotherapy and perspectives for molecular-based oncological treatment in pediatric hemispheric low-grade gliomas.

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9.  Enhanced protection against renal ischemia-reperfusion injury with combined melatonin and exendin-4 in a rodent model.

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10.  Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity.

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