OBJECTIVE: To determine the predictive value of preconceptional peripheral blood natural killer (pNK) cell activity in patients with recurrent pregnancy loss (RPL). DESIGN: Cohort study. SETTING: University department. PATIENT(S): A total of 552 patients with a history of two to six consecutive miscarriages. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The predictive value of preconceptional pNK cell activity for subsequent miscarriage was analyzed using multivariable logistic regression analysis, with age, number of previous miscarriages, and presence/absence of previous live births and bed rest as covariates. RESULT(S): Age and number of previous miscarriages, but not high pNK cell activity, were found to be independent risk factors for a subsequent miscarriage. No effect of bed rest and previous live birth on the likelihood of live birth was observed (odds ratios 1.28 [95% confidence interval 0.81-2.02] and 0.91 [0.52-1.59], respectively). CONCLUSION(S): Elevated pNK cell activity was found to not be an independent risk factor for subsequent miscarriage. Clinicians should not measure the plasma NK activity as a systematic recurrent pregnancy loss examination, because its clinical significance is yet to be established.
OBJECTIVE: To determine the predictive value of preconceptional peripheral blood natural killer (pNK) cell activity in patients with recurrent pregnancy loss (RPL). DESIGN: Cohort study. SETTING: University department. PATIENT(S): A total of 552 patients with a history of two to six consecutive miscarriages. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The predictive value of preconceptional pNK cell activity for subsequent miscarriage was analyzed using multivariable logistic regression analysis, with age, number of previous miscarriages, and presence/absence of previous live births and bed rest as covariates. RESULT(S): Age and number of previous miscarriages, but not high pNK cell activity, were found to be independent risk factors for a subsequent miscarriage. No effect of bed rest and previous live birth on the likelihood of live birth was observed (odds ratios 1.28 [95% confidence interval 0.81-2.02] and 0.91 [0.52-1.59], respectively). CONCLUSION(S): Elevated pNK cell activity was found to not be an independent risk factor for subsequent miscarriage. Clinicians should not measure the plasma NK activity as a systematic recurrent pregnancy loss examination, because its clinical significance is yet to be established.
Authors: P Triggianese; C Perricone; P Conigliaro; M S Chimenti; R Perricone; C De Carolis Journal: Int J Immunopathol Pharmacol Date: 2015-12-10 Impact factor: 3.219
Authors: Chow-Seng Kong; Alexandra Almansa Ordoñez; Sarah Turner; Tina Tremaine; Joanne Muter; Emma S Lucas; Emma Salisbury; Rita Vassena; Gustavo Tiscornia; Ali A Fouladi-Nashta; Geraldine Hartshorne; Jan J Brosens; Paul J Brighton Journal: FASEB J Date: 2021-04 Impact factor: 5.834
Authors: Boris V Dons'koi; Victor P Chernyshov; Dariia V Osypchuk; Irina Sudoma; Kseniia G Khazhylenko; Galina V Strelko; Wera J Sirenko Journal: Cent Eur J Immunol Date: 2020-11-01 Impact factor: 2.085