Literature DB >> 24011883

Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment.

Nikolaos P Daskalakis1, Amy Lehrner, Rachel Yehuda.   

Abstract

Post-traumatic stress disorder (PTSD) is a serious, multisystem disorder with multiple medical comorbidities. This article reviews the current literature on the endocrine aspects of PTSD, specifically hypothalamic-pituitary-adrenal axis alterations indicative of low cortisol and increased glucocorticoid sensitivity, and the proposed mechanisms whereby these alterations increase risk or reflect pathophysiology. Discussion includes novel treatment innovations and directions for future research.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cortisol; Hypothalamic-pituitary-adrenal axis; Post-traumatic stress disorder; Stress; Sympathetic

Mesh：

Substances：

Year:  2013        PMID： 24011883     DOI： 10.1016/j.ecl.2013.05.004

Source DB:  PubMed          Journal:  Endocrinol Metab Clin North Am        ISSN： 0889-8529            Impact factor:   4.741


  55 in total

Review 1.  Recent Genetics and Epigenetics Approaches to PTSD.

Authors:  Nikolaos P Daskalakis; Chuda M Rijal; Christopher King; Laura M Huckins; Kerry J Ressler
Journal:  Curr Psychiatry Rep       Date:  2018-04-05       Impact factor: 5.285

2.  Post-traumatic stress avoidance is attenuated by corticosterone and associated with brain levels of steroid receptor co-activator-1 in rats.

Authors:  Annie M Whitaker; Muhammad A Farooq; Scott Edwards; Nicholas W Gilpin
Journal:  Stress       Date:  2015-10-20       Impact factor: 3.493

3.  Glucocorticoid-related predictors and correlates of post-traumatic stress disorder treatment response in combat veterans.

Authors:  Rachel Yehuda; Laura C Pratchett; Matthew W Elmes; Amy Lehrner; Nikolaos P Daskalakis; Erin Koch; Iouri Makotkine; Janine D Flory; Linda M Bierer
Journal:  Interface Focus       Date:  2014-10-06       Impact factor: 3.906

4.  Blunted hypothalamo-pituitary adrenal axis response to predator odor predicts high stress reactivity.

Authors:  Annie M Whitaker; Nicholas W Gilpin
Journal:  Physiol Behav       Date:  2015-03-27

5.  Impact of early life adversity on the stress biobehavioral response during nicotine withdrawal.

Authors:  Mustafa al'Absi; Motohiro Nakajima; Andrine Lemieux
Journal:  Psychoneuroendocrinology       Date:  2018-08-15       Impact factor: 4.905

Review 6.  New translational perspectives for blood-based biomarkers of PTSD: From glucocorticoid to immune mediators of stress susceptibility.

Authors:  Nikolaos P Daskalakis; Hagit Cohen; Caroline M Nievergelt; Dewleen G Baker; Joseph D Buxbaum; Scott J Russo; Rachel Yehuda
Journal:  Exp Neurol       Date:  2016-07-29       Impact factor: 5.330

Review 7.  Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic.

Authors:  John H Krystal; Chadi G Abdallah; Lynette A Averill; Benjamin Kelmendi; Ilan Harpaz-Rotem; Gerard Sanacora; Steven M Southwick; Ronald S Duman
Journal:  Curr Psychiatry Rep       Date:  2017-08-26       Impact factor: 5.285

Review 8.  Neurobiology of comorbid post-traumatic stress disorder and alcohol-use disorder.

Authors:  N W Gilpin; J L Weiner
Journal:  Genes Brain Behav       Date:  2016-11-18       Impact factor: 3.449

Review 9.  The predator odor avoidance model of post-traumatic stress disorder in rats.

Authors:  Lucas Albrechet-Souza; Nicholas W Gilpin
Journal:  Behav Pharmacol       Date:  2019-04       Impact factor: 2.293

Review 10.  Animal models for posttraumatic stress disorder: An overview of what is used in research.

Authors:  Bart Borghans; Judith R Homberg
Journal:  World J Psychiatry       Date:  2015-12-22
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