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Literature DB >> 24011710

Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders.

Hui Chen^1,2, Annie Y Chan^1,2, Donald U Stone^1,2, Nawajes A Mandal^1,2.

Abstract

Sphingolipids are a ubiquitous membrane lipid present in every cell and found most abundantly in neural tissues. Disorders such as Tay-Sachs or Niemann-Pick disease are the most familiar examples of dysfunction in sphingolipid metabolism and are typically associated with neurodegeneration and ocular findings such as blindness. More recently, the role of bioactive sphingolipids has been established in a multitude of cellular events, including cell survival, growth, senescence and apoptosis, inflammation, and neovascularization. We discuss our current knowledge and understanding of sphingolipid metabolism and signaling in the pathogenesis of ocular diseases.

Entities: Chemical Disease Gene Species

Keywords: FTY720; ceramide; retina; retinal degenerations; sphingolipid; sphingosine; uveitis

Mesh：

Substances：
Sphingolipids

Year: 2013 PMID： 24011710 PMCID： PMC3864975 DOI： 10.1016/j.survophthal.2013.02.005

Source DB: PubMed Journal: Surv Ophthalmol ISSN： 0039-6257 Impact factor: 6.048

149 in total

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18 in total

1. [Cherry-red spot in a 13-month-old child].

Authors: B Hohberger; N Stenger; R Trollmann; C Y Mardin; G-C Gusek-Schneider
Journal: Ophthalmologe Date: 2017-05 Impact factor: 1.059

2. Overexpression of acid ceramidase (ASAH1) protects retinal cells (ARPE19) from oxidative stress.

Authors: Eriko Sugano; Genea Edwards; Saikat Saha; Lynda A Wilmott; Richard C Grambergs; Koushik Mondal; Hui Qi; Megan Stiles; Hiroshi Tomita; Nawajes Mandal
Journal: J Lipid Res Date: 2018-11-09 Impact factor: 5.922

3. Analysis of sphingolipid composition in human vitreous from control and diabetic individuals.

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Journal: J Diabetes Complications Date: 2018-12-14 Impact factor: 2.852

4. Amyotrophy, cerebellar impairment and psychiatric disease are the main symptoms in a cohort of 14 Czech patients with the late-onset form of Tay-Sachs disease.

Authors: Helena Jahnová; Helena Poupětová; Jitka Jirečková; Hana Vlášková; Eva Košťálová; Radim Mazanec; Alena Zumrová; Petr Mečíř; Zuzana Mušová; Martin Magner
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Authors: Sara Tucci
Journal: Int J Mol Sci Date: 2022-06-27 Impact factor: 6.208