BACKGROUND: Optimal treatment of Graves' disease (GD) remains controversial. The authors retrospectively reviewed the surgical cases of GD at a single academic tertiary center. METHODS: Demographic, clinical, and surgical data were analyzed for all patients with GD undergoing thyroidectomy over 25 years, in 3 periods: 1985 to 1993 (n = 32), 1994 to 2002 (n = 91), and 2003 to 2010 (n = 177). RESULTS: There were 300 patients with GD (85.7% women; mean age, 39.3 years; median length of follow-up, 24.6 months). Overall, perioperative morbidity occurred in 36 patients (12.0%), and there was no mortality. Thyroidectomy-specific morbidity was very low, and the incidental malignancy rate was 10.3%. CONCLUSIONS: Surgical treatment of GD has a very high safety profile, with low perioperative and thyroidectomy-specific morbidity, even in patients with overt hyperthyroidism. Incidental malignancy in patients with GD is not uncommon.
BACKGROUND: Optimal treatment of Graves' disease (GD) remains controversial. The authors retrospectively reviewed the surgical cases of GD at a single academic tertiary center. METHODS: Demographic, clinical, and surgical data were analyzed for all patients with GD undergoing thyroidectomy over 25 years, in 3 periods: 1985 to 1993 (n = 32), 1994 to 2002 (n = 91), and 2003 to 2010 (n = 177). RESULTS: There were 300 patients with GD (85.7% women; mean age, 39.3 years; median length of follow-up, 24.6 months). Overall, perioperative morbidity occurred in 36 patients (12.0%), and there was no mortality. Thyroidectomy-specific morbidity was very low, and the incidental malignancy rate was 10.3%. CONCLUSIONS: Surgical treatment of GD has a very high safety profile, with low perioperative and thyroidectomy-specific morbidity, even in patients with overt hyperthyroidism. Incidental malignancy in patients with GD is not uncommon.
Authors: Domenic Vital; Grégoire B Morand; Christian Meerwein; Roman D Laske; Hans C Steinert; Christoph Schmid; Michelle L Brown; Gerhard F Huber Journal: World J Surg Date: 2017-10 Impact factor: 3.352
Authors: Dominik A Jakob; Philipp Riss; Christian Scheuba; Michael Hermann; Corina Kim-Fuchs; Christian A Seiler; Martin A Walter; Reto M Kaderli Journal: World J Surg Date: 2019-09 Impact factor: 3.352
Authors: Detlef K Bartsch; Markus Luster; Heinz J Buhr; Dietmar Lorenz; Christoph-Thomas Germer; Peter E Goretzki Journal: Dtsch Arztebl Int Date: 2018-01-08 Impact factor: 5.594
Authors: Fabio Medas; Ernico Erdas; Gian Luigi Canu; Alessandro Longheu; Giuseppe Pisano; Massimiliano Tuveri; Pietro Giorgio Calò Journal: J Otolaryngol Head Neck Surg Date: 2018-01-22