Cynthia Brady1, Patricia Ackerman2, Mahrya Johnson2, John McNamara3. 1. Children's Hospitals and Clinics of MN, Center for Cystic Fibrosis, 2525 Chicago Avenue South, Minneapolis, MN 55404, United States; Children's Respiratory and Critical Care Specialists, 2530 Chicago Avenue South, Minneapolis, MN 55404, United States. Electronic address: brady@crccs.com. 2. Children's Hospitals and Clinics of MN, Center for Cystic Fibrosis, 2525 Chicago Avenue South, Minneapolis, MN 55404, United States. 3. Children's Hospitals and Clinics of MN, Center for Cystic Fibrosis, 2525 Chicago Avenue South, Minneapolis, MN 55404, United States; Children's Respiratory and Critical Care Specialists, 2530 Chicago Avenue South, Minneapolis, MN 55404, United States.
Abstract
BACKGROUND: Bordetella bronchiseptica is a common pathogenic or colonizing organism of domestic mammals. In dogs, it causes an infectious tracheobronchitis known as Kennel Cough. Human infections are unusual and almost exclusively described in immunocompromised patients who have had contact with a known animal reservoir. It is rarely reported in Cystic Fibrosis (CF), possibly hampered by low recovery from culture and organism misidentification. We describe the incidence and characteristics of B. bronchiseptica in our CF population. METHODS: A retrospective cohort study was conducted of our center's CF patient population. Patients were included if they had B. bronchiseptica isolated on one or more occasion. RESULTS: Seven children with CF isolated B. bronchiseptica on 23 occasions, frequently associated with the symptoms of a pulmonary exacerbation. Four patients required hospitalization. CONCLUSION: These results suggest that B. bronchiseptica may be more common than previously reported and may play a potential pathogenic role in CF.
BACKGROUND: Bordetella bronchiseptica is a common pathogenic or colonizing organism of domestic mammals. In dogs, it causes an infectious tracheobronchitis known as Kennel Cough. Human infections are unusual and almost exclusively described in immunocompromised patients who have had contact with a known animal reservoir. It is rarely reported in Cystic Fibrosis (CF), possibly hampered by low recovery from culture and organism misidentification. We describe the incidence and characteristics of B. bronchiseptica in our CF population. METHODS: A retrospective cohort study was conducted of our center's CF patient population. Patients were included if they had B. bronchiseptica isolated on one or more occasion. RESULTS: Seven children with CF isolated B. bronchiseptica on 23 occasions, frequently associated with the symptoms of a pulmonary exacerbation. Four patients required hospitalization. CONCLUSION: These results suggest that B. bronchiseptica may be more common than previously reported and may play a potential pathogenic role in CF.
Authors: H E Daligault; K W Davenport; T D Minogue; K A Bishop-Lilly; D C Bruce; P S Chain; S R Coyne; K G Frey; J Jaissle; G I Koroleva; J T Ladner; C-C Lo; L Meincke; C Munk; G F Palacios; C L Redden; S L Johnson Journal: Genome Announc Date: 2014-09-18
Authors: Andrea Hahn; Aszia Burrell; Hani Fanous; Hollis Chaney; Iman Sami; Geovanny F Perez; Anastassios C Koumbourlis; Robert J Freishtat; Keith A Crandall Journal: Heliyon Date: 2018-09-17