OBJECTIVES: To assess the value of PET/MRI with [(18)F]-FDG using a whole body protocol for the depiction and characterization of liver lesions in comparison to PET/CT. METHODS: 70 patients (31 women, 39 men) with solid tumors underwent [(18)F]-FDG PET/CT and followed by an additional PET/MRI using an integrated scanner. Two readers rated the datasets (PET/CT; PET/MRI) regarding conspicuity of hepatic lesions (4-point ordinal scale) and diagnostic confidence (5-point ordinal scale). Median scores for lesion conspicuity and diagnostic confidence were compared using Wilcoxon's rank sum test. Prior examinations, histopathology and clinical follow-up (116 ± 54 days) served as standard of reference. RESULTS: 36 of 70 (51%) patients showed liver lesions. Using PET/CT and PET/MRI all patients with liver metastases could correctly be identified. A total of 97 lesions were found (malignant n=26; benign n=71). For lesion conspicuity significantly higher scores were obtained for PET/MRI in comparison to PET/CT (p<0.001). Significantly better performance for diagnostic confidence was observed in PET/MRI, both for malignant as for benign lesions (p<0.001). CONCLUSIONS: PET/MRI, even in the setting of a whole body approach, provides higher lesion conspicuity and diagnostic confidence compared to PET/CT and may therefore evolve as an attractive alternative in oncologic imaging.
OBJECTIVES: To assess the value of PET/MRI with [(18)F]-FDG using a whole body protocol for the depiction and characterization of liver lesions in comparison to PET/CT. METHODS: 70 patients (31 women, 39 men) with solid tumors underwent [(18)F]-FDG PET/CT and followed by an additional PET/MRI using an integrated scanner. Two readers rated the datasets (PET/CT; PET/MRI) regarding conspicuity of hepatic lesions (4-point ordinal scale) and diagnostic confidence (5-point ordinal scale). Median scores for lesion conspicuity and diagnostic confidence were compared using Wilcoxon's rank sum test. Prior examinations, histopathology and clinical follow-up (116 ± 54 days) served as standard of reference. RESULTS: 36 of 70 (51%) patients showed liver lesions. Using PET/CT and PET/MRI all patients with liver metastases could correctly be identified. A total of 97 lesions were found (malignant n=26; benign n=71). For lesion conspicuity significantly higher scores were obtained for PET/MRI in comparison to PET/CT (p<0.001). Significantly better performance for diagnostic confidence was observed in PET/MRI, both for malignant as for benign lesions (p<0.001). CONCLUSIONS: PET/MRI, even in the setting of a whole body approach, provides higher lesion conspicuity and diagnostic confidence compared to PET/CT and may therefore evolve as an attractive alternative in oncologic imaging.
Authors: Benedikt Schaarschmidt; Christian Buchbender; Benedikt Gomez; Christian Rubbert; Florian Hild; Jens Köhler; Johannes Grueneisen; Henning Reis; Verena Ruhlmann; Axel Wetter; Harald H Quick; Gerald Antoch; Philipp Heusch Journal: Eur J Nucl Med Mol Imaging Date: 2015-04-08 Impact factor: 9.236
Authors: Youssef Erfanian; Johannes Grueneisen; Julian Kirchner; Axel Wetter; Lars Erik Podleska; Sebastian Bauer; Thorsten Poeppel; Michael Forsting; Ken Herrmann; Lale Umutlu Journal: Eur J Nucl Med Mol Imaging Date: 2017-05-31 Impact factor: 9.236
Authors: Benedikt M Schaarschmidt; Johannes Grueneisen; Martin Metzenmacher; Benedikt Gomez; Thomas Gauler; Christian Roesel; Philipp Heusch; Verena Ruhlmann; Lale Umutlu; Gerald Antoch; Christian Buchbender Journal: Eur Radiol Date: 2016-05-14 Impact factor: 5.315