OBJECT: Transcranial Doppler (TCD) is frequently used to evaluate peripheral cerebral resistance and cerebral blood flow (CBF) in the middle cerebral artery prior to and during carotid endarterectomy (CEA). Patients with symptomatic carotid artery stenosis may have reduced peripheral cerebral resistance to compensate for inadequate CBF. The authors aim to determine whether symptomatic patients with reduced peripheral cerebral resistance prior to CEA demonstrate increased CBF and cognitive improvement as early as 1 day after CEA. METHODS: Fifty-three patients with symptomatic CEA were included in this observational study. All patients underwent neuropsychometric evaluation 24 hours or less preoperatively and 1 day postoperatively. The MCA was evaluated using TCD for CBF mean velocity (MV) and pulsatility index (PI). Pulsatility index ≤ 0.80 was used as a cutoff for reduced peripheral cerebral resistance. RESULTS: Significantly more patients with baseline PI ≤ 0.80 exhibited cognitive improvement 1 day after CEA than those with PI > 0.80 (35.0% vs 6.1%, p = 0.007). Patients with cognitive improvement had a significantly greater increase in CBF MV than patients without cognitive improvement (13.4 ± 17.1 cm/sec vs 4.3 ± 9.9 cm/sec, p = 0.03). In multivariate regression model, a baseline PI ≤ 0.80 was significantly associated with increased odds of cognitive improvement (OR 7.32 [1.40-59.49], p = 0.02). CONCLUSIONS: Symptomatic CEA patients with reduced peripheral cerebral resistance, measured as PI ≤ 0.80, are likely to have increased CBF and improved cognitive performance as early as 1 day after CEA for symptomatic carotid artery stenosis. Revascularization in this cohort may afford benefits beyond prevention of future stroke. Clinical trial registration no: NCT00597883 ( ClinicalTrials.gov ).
OBJECT: Transcranial Doppler (TCD) is frequently used to evaluate peripheral cerebral resistance and cerebral blood flow (CBF) in the middle cerebral artery prior to and during carotid endarterectomy (CEA). Patients with symptomatic carotid artery stenosis may have reduced peripheral cerebral resistance to compensate for inadequate CBF. The authors aim to determine whether symptomatic patients with reduced peripheral cerebral resistance prior to CEA demonstrate increased CBF and cognitive improvement as early as 1 day after CEA. METHODS: Fifty-three patients with symptomatic CEA were included in this observational study. All patients underwent neuropsychometric evaluation 24 hours or less preoperatively and 1 day postoperatively. The MCA was evaluated using TCD for CBF mean velocity (MV) and pulsatility index (PI). Pulsatility index ≤ 0.80 was used as a cutoff for reduced peripheral cerebral resistance. RESULTS: Significantly more patients with baseline PI ≤ 0.80 exhibited cognitive improvement 1 day after CEA than those with PI > 0.80 (35.0% vs 6.1%, p = 0.007). Patients with cognitive improvement had a significantly greater increase in CBF MV than patients without cognitive improvement (13.4 ± 17.1 cm/sec vs 4.3 ± 9.9 cm/sec, p = 0.03). In multivariate regression model, a baseline PI ≤ 0.80 was significantly associated with increased odds of cognitive improvement (OR 7.32 [1.40-59.49], p = 0.02). CONCLUSIONS: Symptomatic CEA patients with reduced peripheral cerebral resistance, measured as PI ≤ 0.80, are likely to have increased CBF and improved cognitive performance as early as 1 day after CEA for symptomatic carotid artery stenosis. Revascularization in this cohort may afford benefits beyond prevention of future stroke. Clinical trial registration no: NCT00597883 ( ClinicalTrials.gov ).
Authors: Ramez R Moustafa; David Izquierdo-Garcia; P Simon Jones; Martin J Graves; Tim D Fryer; Jonathan H Gillard; Elizabeth A Warburton; Jean-Claude Baron Journal: Stroke Date: 2010-05-27 Impact factor: 7.914
Authors: G Telman; E Kouperberg; S Nitecki; T Karram; H A Schwarz; E Sprecher; A Hoffman; D Yarnitsky Journal: Eur J Vasc Endovasc Surg Date: 2006-06-15 Impact factor: 7.069
Authors: T Brott; T Tomsick; W Feinberg; C Johnson; J Biller; J Broderick; M Kelly; J Frey; S Schwartz; C Blum Journal: Stroke Date: 1994-06 Impact factor: 7.914
Authors: M A Sloan; A V Alexandrov; C H Tegeler; M P Spencer; L R Caplan; E Feldmann; L R Wechsler; D W Newell; C R Gomez; V L Babikian; D Lefkowitz; R S Goldman; C Armon; C Y Hsu; D S Goodin Journal: Neurology Date: 2004-05-11 Impact factor: 9.910
Authors: Eric J Heyer; Robert DeLaPaz; Hadi J Halazun; Anita Rampersad; Robert Sciacca; Joseph Zurica; Alan I Benvenisty; Donald O Quest; George J Todd; Sean Lavine; Robert A Solomon; E Sander Connolly Journal: Neurosurgery Date: 2006-03 Impact factor: 4.654
Authors: Kevin S Heffernan; Nicole L Spartano; Jacqueline A Augustine; Wesley K Lefferts; William E Hughes; Gary F Mitchell; Randall S Jorgensen; Brooks B Gump Journal: Am J Hypertens Date: 2014-11-10 Impact factor: 2.689
Authors: Jian Wang; Weici Wang; Bi Jin; Yanrong Zhang; Ping Xu; Feixiang Xiang; Yi Zheng; Juan Chen; Shi Sheng; Chenxi Ouyang; Yiqing Li Journal: Biomed Res Int Date: 2016-08-23 Impact factor: 3.411