Literature DB >> 24010182

Elimination of long-term potentiation in the hippocampus by phencyclidine and ketamine.

J L Stringer1, P G Guyenet.   

Abstract

Long-term potentiation (LTP) of CA1 population spikes was elicited by cCA3 stimulation. Phencyclidine (PCP) and ketamine blocked the potentiation in a dose-dependent manner while diazepam and sodium thiopental had no effect. In midcollicular-transected rats where PCP has no depressant effect on the population spike, the drug still blocked LTP.

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Year:  1983        PMID： 24010182     DOI： 10.1016/0006-8993(83)91244-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

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