Literature DB >> 2400925

Localization of the mRNA for the 5-HT2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites.

G Mengod1, M Pompeiano, M I Martínez-Mir, J M Palacios.   

Abstract

32P-labelled oligonucleotides complementary to rat 5-HT2 receptor mRNA were used as probes to study the distribution of cells in rat brain containing the mRNA coding for this receptor by in situ hybridization histochemistry. 5-HT2 receptor binding sites were visualized by autoradiography using [125I]DOI as ligand. Both distributions were comparable, demonstrating that 5-HT2 receptors are expressed by cells intrinsic to the neocortex (lamina Va), claustrum, olfactory bulb and several nuclei of the brainstem.

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Year:  1990        PMID： 2400925     DOI： 10.1016/0006-8993(90)90502-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  37 in total

1.  DOI-Induced activation of the cortex: dependence on 5-HT2A heteroceptors on thalamocortical glutamatergic neurons.

Authors:  J L Scruggs; S Patel; M Bubser; A Y Deutch
Journal:  J Neurosci       Date:  2000-12-01       Impact factor: 6.167

2.  Serotonin 5-HT2C receptor protein expression is enriched in synaptosomal and post-synaptic compartments of rat cortex.

Authors:  Noelle C Anastasio; Maria Fe Lanfranco; Marcy J Bubar; Patricia K Seitz; Sonja J Stutz; Andrew G McGinnis; Cheryl S Watson; Kathryn A Cunningham
Journal:  J Neurochem       Date:  2010-03-24       Impact factor: 5.372

Review 3.  Autoradiographical and immunohistochemical analysis of receptor localization in the central nervous system.

Authors:  J G Chabot; S Kar; R Quirion
Journal:  Histochem J       Date:  1996-11

4.  Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex.

Authors:  C Nocjar; K D Alex; A Sonneborn; A I Abbas; B L Roth; E A Pehek
Journal:  Neuroscience       Date:  2015-03-27       Impact factor: 3.590

5.  Synthesis and Evaluation of Pyridyloxypyridyl Indole Carboxamides as Potential PET Imaging Agents for 5-HT2C Receptors.

Authors:  Fanxing Zeng; Jonathon A Nye; Ronald J Voll; Leonard Howell; Mark M Goodman
Journal:  ACS Med Chem Lett       Date:  2018-02-05       Impact factor: 4.345

Review 6.  Estrogen control of central neurotransmission: effect on mood, mental state, and memory.

Authors:  G Fink; B E Sumner; R Rosie; O Grace; J P Quinn
Journal:  Cell Mol Neurobiol       Date:  1996-06       Impact factor: 5.046

7.  Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.

Authors:  Alice M Holohean; John C Hackman
Journal:  Br J Pharmacol       Date:  2004-08-31       Impact factor: 8.739

8.  Synthesis and evaluation of methylated arylazepine compounds for PET imaging of 5-HT(2c) receptors.

Authors:  Michael L Granda; Stephen M Carlin; Christian K Moseley; Ramesh Neelamegam; Joseph B Mandeville; Jacob M Hooker
Journal:  ACS Chem Neurosci       Date:  2012-12-07       Impact factor: 4.418

9.  Dopamine receptor agonists regulate levels of the serotonin 5-HT2A receptor and its mRNA in a subpopulation of rat striatal neurons.

Authors:  N Laprade; F Radja; T A Reader; J J Soghomonian
Journal:  J Neurosci       Date:  1996-06-01       Impact factor: 6.167

10.  Changes in serotonin metabolism may elicit obstructive apnoea in the newborn rat.

Authors:  G Hilaire; D Morin; A M Lajard; R Monteau
Journal:  J Physiol       Date:  1993-07       Impact factor: 5.182
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