BACKGROUND: Extensive neuromotor development occurs early in human life, but the time that a brain injury occurs during development has not been rigorously studied when quantifying motor impairments. OBJECTIVE: This study investigated the impact of timing of brain injury on the magnitude and distribution of weakness in the paretic arm of individuals with childhood-onset hemiparesis. METHODS: A total of 24 individuals with hemiparesis were divided into time periods of injury before birth (PRE-natal, n = 8), around the time of birth (PERI-natal, n = 8), or after 6 months of age (POST-natal, n = 8). They, along with 8 typically developing peers, participated in maximal isometric shoulder, elbow, wrist, and finger torque generation tasks using a multiple-degree-of-freedom load cell to quantify torques in 10 directions. A mixed-model ANOVA was used to determine the effect of group and task on a calculated relative weakness ratio between arms. RESULTS: There was a significant effect of both time of injury group (P < .001) and joint torque direction (P < .001) on the relative weakness of the paretic arm. Distal joints were more affected compared with proximal joints, especially in the POST-natal group. CONCLUSIONS: The distribution of weakness provides evidence for the relative preservation of ipsilateral corticospinal motor pathways to the paretic limb in those individuals injured earlier, whereas those who sustained later injury may rely more on indirect ipsilateral corticobulbospinal projections during the generation of torques with the paretic arm.
BACKGROUND: Extensive neuromotor development occurs early in human life, but the time that a brain injury occurs during development has not been rigorously studied when quantifying motor impairments. OBJECTIVE: This study investigated the impact of timing of brain injury on the magnitude and distribution of weakness in the paretic arm of individuals with childhood-onset hemiparesis. METHODS: A total of 24 individuals with hemiparesis were divided into time periods of injury before birth (PRE-natal, n = 8), around the time of birth (PERI-natal, n = 8), or after 6 months of age (POST-natal, n = 8). They, along with 8 typically developing peers, participated in maximal isometric shoulder, elbow, wrist, and finger torque generation tasks using a multiple-degree-of-freedom load cell to quantify torques in 10 directions. A mixed-model ANOVA was used to determine the effect of group and task on a calculated relative weakness ratio between arms. RESULTS: There was a significant effect of both time of injury group (P < .001) and joint torque direction (P < .001) on the relative weakness of the paretic arm. Distal joints were more affected compared with proximal joints, especially in the POST-natal group. CONCLUSIONS: The distribution of weakness provides evidence for the relative preservation of ipsilateral corticospinal motor pathways to the paretic limb in those individuals injured earlier, whereas those who sustained later injury may rely more on indirect ipsilateral corticobulbospinal projections during the generation of torques with the paretic arm.
Authors: Laura C Miller; Christopher K Thompson; Francesco Negro; C J Heckman; Dario Farina; Julius P A Dewald Journal: Conf Proc IEEE Eng Med Biol Soc Date: 2014
Authors: Kathleen M Friel; Preston T J A Williams; Najet Serradj; Samit Chakrabarty; John H Martin Journal: Front Neurol Date: 2014-11-24 Impact factor: 4.003
Authors: Simone Wolter; Hannes Haberl; Claudia Spies; T Alp Sargut; John H Martin; Sascha Tafelski; Anne van Riesen; Ingeborg Küchler; Brigitte Wegner; Kathrin Scholtz; Ulrich-W Thomale; Theodor Michael; James F Murphy; Matthias Schulz Journal: Childs Nerv Syst Date: 2020-06-25 Impact factor: 1.475
Authors: Sylvia Synowiec; Jing Lu; Lei Yu; Ivan Goussakov; Richard Lieber; Alexander Drobyshevsky Journal: Front Neurol Date: 2019-01-17 Impact factor: 4.003