OBJECTIVE: To compare two remifentanil doses (1 µg/kg and 2 µg/kg) in order to determine the preferred dose in intellectually disabled patients undergoing day care dental surgery undersevoflurane-induced general anaesthesia. METHODS: Patients were randomly assigned to receive either 1 µg/kg (group 1) or 2 µg/kg (group 2) remifentanil; both groups received 8% sevoflurane anaesthesia induction. All other conditions were identical in both groups. Heart rate (HR), mean arterial pressure (MAP) and intubation conditions were assessed. RESULTS: A total of 27/30 (90.0%) patients in group 1 and 29/30 patients (96.7%) in group 2 had acceptable intubation conditions. Remifentanil administration resulted in significant reductions in HR compared with baseline levels, in both groups. There were no significant between-group differences in HR at any timepoint. MAP decreased significantly compared with baseline in group 2 only. CONCLUSION: Successful tracheal intubation in intellectually disabled patients can be accomplished with a combination of 1 µg/kg or 2 µg/kg remifentanil and 8% sevoflurane anaesthesia induction, without the requirement for neuromuscular blocking drugs.
RCT Entities:
OBJECTIVE: To compare two remifentanil doses (1 µg/kg and 2 µg/kg) in order to determine the preferred dose in intellectually disabled patients undergoing day care dental surgery under sevoflurane-induced general anaesthesia. METHODS:Patients were randomly assigned to receive either 1 µg/kg (group 1) or 2 µg/kg (group 2) remifentanil; both groups received 8% sevoflurane anaesthesia induction. All other conditions were identical in both groups. Heart rate (HR), mean arterial pressure (MAP) and intubation conditions were assessed. RESULTS: A total of 27/30 (90.0%) patients in group 1 and 29/30 patients (96.7%) in group 2 had acceptable intubation conditions. Remifentanil administration resulted in significant reductions in HR compared with baseline levels, in both groups. There were no significant between-group differences in HR at any timepoint. MAP decreased significantly compared with baseline in group 2 only. CONCLUSION: Successful tracheal intubation in intellectually disabled patients can be accomplished with a combination of 1 µg/kg or 2 µg/kg remifentanil and 8% sevoflurane anaesthesia induction, without the requirement for neuromuscular blocking drugs.
Entities:
Keywords:
Remifentanil; day care surgery; endotracheal intubation; neuromuscular block
Authors: Thomas Mencke; Refa Maria Jacobs; Susann Machmueller; Martin Sauer; Christine Heidecke; Anja Kallert; Hans Wilhelm Pau; Gabriele Noeldge-Schomburg; Attila Ovari Journal: BMC Anesthesiol Date: 2014-05-22 Impact factor: 2.217
Authors: Attila Ovari; Ilona Bicker; Susann Machmueller; Tobias Schuldt; Martin Sauer; Stefan Soltesz; Gabriele Noeldge-Schomburg; Robert Mlynski; Thomas Mencke Journal: J Int Med Res Date: 2017-04-28 Impact factor: 1.671