| Literature DB >> 24008124 |
Chika Sakai1, Eriko Tomitsuka, Makoto Miyagishi, Shigeharu Harada, Kiyoshi Kita.
Abstract
The flavoprotein (Fp) subunit of human mitochondrial succinate-ubiquinone reductase (SQR, complex II) has isoforms (type I, type II). Type II Fp is predominantly expressed in some cancer and fetal tissues and those tissues are often exposed to ischemia. The present study shows that complex II with type II Fp has lower optimal pH than complex II with type I Fp, and type II Fp mRNA expression was induced by ischemia. The result suggests complex II with type II Fp may function in cells with low mitochondrial matrix pH caused by ischemia and its function is related to cellular adaptation to ischemia.Entities:
Keywords: 0.1mM 5,5′-dithiobis-(2-nitrobenzoic acid); 2,6-dichlorophenolindophenol; 3-NP; 3-nitropropionic acid; 50% inhibitory concentration; Complex II; DCIP; DTNB; Flavoprotein; Fp; Fumarate respiration; HIF-1α; Human mitochondria; IC(50); QFR; SDHAF1; SDHAF2; SML; SQR; Succinate-ubiquinone reductase; flavoprotein; hypoxia-inducible factor-1α; quinol-fumarate reductase; succinate-dehydrogenase assembly factor 1; succinate-dehydrogenase assembly factor 2; succinate-ubiquinone reductase; sucrose monolaurate
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Year: 2013 PMID： 24008124 DOI： 10.1016/j.mito.2013.08.009
Source DB: PubMed Journal: Mitochondrion ISSN： 1567-7249 Impact factor: 4.160