Literature DB >> 24004673

Coamplification and cooperation: toward identifying biologically relevant oncogenes.

Guochang Huang1, Bhuvanesh Singh.   

Abstract

Identification of biologically relevant genes from genomic assays is limited by the complexity of changes present in most solid tumors. Assessing for coactivation of functionally related genes resulted in the identification of SENP2, DCUN1D1, and DVL3--consensus candidates that drive selection for 3q amplification in lung squamous cell carcinomas. ©2013 AACR.

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Mesh：

Year:  2013        PMID： 24004673      PMCID： PMC4147724          DOI： 10.1158/1078-0432.CCR-13-2117

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  11 in total

1.  Molecular cytogenetic characterization of head and neck squamous cell carcinoma and refinement of 3q amplification.

Authors:  B Singh; S K Gogineni; P G Sacks; A R Shaha; J P Shah; A Stoffel; P H Rao
Journal:  Cancer Res       Date:  2001-06-01       Impact factor: 12.701

Review 2.  Genomics and the continuum of cancer care.

Authors:  Ultan McDermott; James R Downing; Michael R Stratton
Journal:  N Engl J Med       Date:  2011-01-27       Impact factor: 91.245

3.  Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas.

Authors:  Inderpal Sarkaria; Pornchai O-charoenrat; Simon G Talbot; Pabbathi G Reddy; Ivan Ngai; Ellie Maghami; Kepal N Patel; Benjamin Lee; Yoshihiro Yonekawa; Maria Dudas; Andrew Kaufman; Russell Ryan; Ronald Ghossein; Pulivarthi H Rao; Archontoula Stoffel; Y Ramanathan; Bhuvanesh Singh
Journal:  Cancer Res       Date:  2006-10-01       Impact factor: 12.701

4.  SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex.

Authors:  Guochang Huang; Andrew J Kaufman; Y Ramanathan; Bhuvanesh Singh
Journal:  J Biol Chem       Date:  2011-01-19       Impact factor: 5.157

5.  SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.

Authors:  Alexander Y Kim; Claire C Bommeljé; Benjamin E Lee; Yoshihiro Yonekawa; Lydia Choi; Luc G Morris; Guochang Huang; Andrew Kaufman; Russel J H Ryan; Bing Hao; Y Ramanathan; Bhuvanesh Singh
Journal:  J Biol Chem       Date:  2008-09-30       Impact factor: 5.157

6.  Evidence that SOX2 overexpression is oncogenic in the lung.

Authors:  Yun Lu; Christopher Futtner; Jason R Rock; Xia Xu; Walter Whitworth; Brigid L M Hogan; Mark W Onaitis
Journal:  PLoS One       Date:  2010-06-10       Impact factor: 3.240

7.  An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.

Authors:  Teresa A Soucy; Peter G Smith; Michael A Milhollen; Allison J Berger; James M Gavin; Sharmila Adhikari; James E Brownell; Kristine E Burke; David P Cardin; Stephen Critchley; Courtney A Cullis; Amanda Doucette; James J Garnsey; Jeffrey L Gaulin; Rachel E Gershman; Anna R Lublinsky; Alice McDonald; Hirotake Mizutani; Usha Narayanan; Edward J Olhava; Stephane Peluso; Mansoureh Rezaei; Michael D Sintchak; Tina Talreja; Michael P Thomas; Tary Traore; Stepan Vyskocil; Gabriel S Weatherhead; Jie Yu; Julie Zhang; Lawrence R Dick; Christopher F Claiborne; Mark Rolfe; Joseph B Bolen; Steven P Langston
Journal:  Nature       Date:  2009-04-09       Impact factor: 49.962

8.  N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex.

Authors:  Daniel C Scott; Julie K Monda; Eric J Bennett; J Wade Harper; Brenda A Schulman
Journal:  Science       Date:  2011-09-22       Impact factor: 47.728

9.  Immunohistochemical Expression of DCUN1D1 in Non-small Cell Lung Carcinoma: Its Relation to Brain Metastasis.

Authors:  Jinyoung Yoo; Seong-Hak Lee; Kwang-Il Lym; Sonya Youngju Park; Seung-Ho Yang; Chang-Young Yoo; Ji-Han Jung; Seok-Jin Kang; Chang-Suk Kang
Journal:  Cancer Res Treat       Date:  2012-03-31       Impact factor: 4.679

10.  SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas.

Authors:  Adam J Bass; Hideo Watanabe; Craig H Mermel; Soyoung Yu; Sven Perner; Roel G Verhaak; So Young Kim; Leslie Wardwell; Pablo Tamayo; Irit Gat-Viks; Alex H Ramos; Michele S Woo; Barbara A Weir; Gad Getz; Rameen Beroukhim; Michael O'Kelly; Amit Dutt; Orit Rozenblatt-Rosen; Piotr Dziunycz; Justin Komisarof; Lucian R Chirieac; Christopher J Lafargue; Veit Scheble; Theresia Wilbertz; Changqing Ma; Shilpa Rao; Hiroshi Nakagawa; Douglas B Stairs; Lin Lin; Thomas J Giordano; Patrick Wagner; John D Minna; Adi F Gazdar; Chang Qi Zhu; Marcia S Brose; Ivan Cecconello; Ulysses Ribeiro; Suely K Marie; Olav Dahl; Ramesh A Shivdasani; Ming-Sound Tsao; Mark A Rubin; Kwok K Wong; Aviv Regev; William C Hahn; David G Beer; Anil K Rustgi; Matthew Meyerson
Journal:  Nat Genet       Date:  2009-10-04       Impact factor: 38.330
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  7 in total

1.  SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).

Authors:  Guochang Huang; Cameron Stock; Claire C Bommeljé; Víola B Weeda; Kushyup Shah; Sarina Bains; Elizabeth Buss; Manish Shaha; Willi Rechler; Suresh Y Ramanathan; Bhuvanesh Singh
Journal:  J Biol Chem       Date:  2014-10-27       Impact factor: 5.157

2.  Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation.

Authors:  Ho Shin Kim; Jared T Hammill; Daniel C Scott; Yizhe Chen; Jaeki Min; Jonah Rector; Bhuvanesh Singh; Brenda A Schulman; R Kiplin Guy
Journal:  J Med Chem       Date:  2019-09-13       Impact factor: 7.446

3.  The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.

Authors:  Guochang Huang; Christopher W Towe; Lydia Choi; Yoshihiro Yonekawa; Claire C Bommeljé; Sarina Bains; Willi Rechler; Bing Hao; Yegnanarayana Ramanathan; Bhuvanesh Singh
Journal:  J Biol Chem       Date:  2014-11-19       Impact factor: 5.157

4.  Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Authors:  Jared T Hammill; Daniel C Scott; Jaeki Min; Michele C Connelly; Gloria Holbrook; Fangyi Zhu; Amy Matheny; Lei Yang; Bhuvanesh Singh; Brenda A Schulman; R Kiplin Guy
Journal:  J Med Chem       Date:  2018-03-26       Impact factor: 7.446

5.  Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Authors:  Jared T Hammill; Deepak Bhasin; Daniel C Scott; Jaeki Min; Yizhe Chen; Yan Lu; Lei Yang; Ho Shin Kim; Michele C Connelly; Courtney Hammill; Gloria Holbrook; Cynthia Jeffries; Bhuvanesh Singh; Brenda A Schulman; R Kiplin Guy
Journal:  J Med Chem       Date:  2018-03-26       Impact factor: 7.446

6.  Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver.

Authors:  Ezra Ella; Denise Heim; Evgeniy Stoyanov; Rona Harari-Steinfeld; Israel Steinfeld; Orit Pappo; Temima Schnitzer Perlman; Natalie Nachmansson; Ludmila Rivkin; Devorah Olam; Rinat Abramovitch; Henning Wege; Eithan Galun; Daniel Goldenberg
Journal:  Oncotarget       Date:  2014-11-15

7.  SOX2 amplification and chromosome 3 gain significantly impact prognosis in esophageal squamous cell carcinoma.

Authors:  Xin Wang; Xiaowen Ge; Haixing Wang; Jie Huang; Qi Song; Chen Xu; Zhengzeng Jiang; Jieakesu Su; Hao Wang; Lijie Tan; Dongxian Jiang; Yingyong Hou
Journal:  Ann Transl Med       Date:  2021-02
  7 in total

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