BACKGROUND: By mixing hydroxyapatite (HA) and tricalcium phosphate (TCP), biphasic calcium phosphate ceramics can be obtained, and by varying their ratio it is possible to tailor the characteristics of the biomaterial. PURPOSE: The aim of the present human study was to evaluate the histological and radiographical aspects of bone formation in maxillary sinus augmentation using a 30/70 HA-beta-TCP with a reticular structure. MATERIALS AND METHODS: A total of 12 patients, undergoing two-stage sinus augmentation procedure using HA-beta-TCP at a ratio of 30/70, were included in the present study. After a 6-month healing period, during implant insertion, radiographical analysis was performed, and then the bone core biopsies were harvested and processed for histology. RESULTS: At radiographic evaluation, the bone gain was on average 6.85 ± 0.60 mm. HA-beta-TCP 30/70 appeared to be lined by newly formed bone, with no gaps at the interface. The histomorphometric analysis revealed 26 ± 2% of residual grafted biomaterial, 29 ± 3% of newly formed bone, and 45 ± 2% of marrow spaces. CONCLUSIONS: The present results indicate histologically the high biocompatibility and osteoconductivity of HA-beta-TCP 30/70, and clinically its successful use for sinus augmentation procedures.
BACKGROUND: By mixing hydroxyapatite (HA) and tricalcium phosphate (TCP), biphasic calcium phosphate ceramics can be obtained, and by varying their ratio it is possible to tailor the characteristics of the biomaterial. PURPOSE: The aim of the present human study was to evaluate the histological and radiographical aspects of bone formation in maxillary sinus augmentation using a 30/70 HA-beta-TCP with a reticular structure. MATERIALS AND METHODS: A total of 12 patients, undergoing two-stage sinus augmentation procedure using HA-beta-TCP at a ratio of 30/70, were included in the present study. After a 6-month healing period, during implant insertion, radiographical analysis was performed, and then the bone core biopsies were harvested and processed for histology. RESULTS: At radiographic evaluation, the bone gain was on average 6.85 ± 0.60 mm. HA-beta-TCP 30/70 appeared to be lined by newly formed bone, with no gaps at the interface. The histomorphometric analysis revealed 26 ± 2% of residual grafted biomaterial, 29 ± 3% of newly formed bone, and 45 ± 2% of marrow spaces. CONCLUSIONS: The present results indicate histologically the high biocompatibility and osteoconductivity of HA-beta-TCP 30/70, and clinically its successful use for sinus augmentation procedures.
Authors: Margherita Tumedei; Eitan Mijiritsky; Carlos Fernando Mourão; Adriano Piattelli; Marco Degidi; Carlo Mangano; Giovanna Iezzi Journal: Int J Environ Res Public Health Date: 2022-06-28 Impact factor: 4.614
Authors: Francesco G Mangano; Marco Colombo; Giovanni Veronesi; Alberto Caprioglio; Carlo Mangano Journal: World J Stem Cells Date: 2015-07-26 Impact factor: 5.326
Authors: Susanna Annibali; Giovanna Iezzi; Gian Luca Sfasciotti; Maria Paola Cristalli; Iole Vozza; Carlo Mangano; Gerardo La Monaca; Antonella Polimeni Journal: Biomed Res Int Date: 2015-07-26 Impact factor: 3.411
Authors: Fabrizia Luongo; Francesco Guido Mangano; Aldo Macchi; Giuseppe Luongo; Carlo Mangano Journal: Biomed Res Int Date: 2016-12-14 Impact factor: 3.411