CONTEXT: Ghrelin is an orexigenic peptide that stimulates food intake, whereas peptide YY (PYY) and cholecystokinin (CCK) are anorexigenic gut hormones. Patients with polycystic ovary syndrome (PCOS) appear to have alterations in appetite regulation. OBJECTIVE: We aimed to determine whether fasting or meal-stimulated ghrelin, PYY, CCK, and satiety responses are different between lean PCOS patients and healthy women. We also aimed to assess the potential effect of oral contraceptive use on these hormones and satiety response. DESIGN AND SETTING: We conducted a prospective observational study in a university practice. PATIENTS: Eighteen lean PCOS patients and 18 healthy control women matched for age and body mass index underwent measurements of circulating ghrelin, PYY, CCK, and satiety index (SI) before and after a standardized mixed meal at 0, 15, 30, 45, 60, 90, 120, and 180 minutes. INTERVENTIONS: For PCOS patients who were treated with ethinyl estradiol 30 μg/drospirenone 3 mg for 3 months, measurements were repeated. MAIN OUTCOME: We measured ghrelin, PYY, and CCK levels and SI. RESULTS: At baseline, fasting ghrelin, PYY, CCK, and SI values in PCOS patients were not different from controls. Meal-stimulated PYY, CCK, and SI were also not different between the groups, whereas PCOS patients had significantly lower meal-stimulated ghrelin levels compared to controls (P = .04). Ghrelin, PYY, CCK, and SI did not show a significant change after treatment with ethinyl estradiol/drospirenone for 3 months. CONCLUSIONS: Basal and stimulated hunger and satiety hormones in lean PCOS patients are not different from lean healthy women, except for a lower meal-stimulated ghrelin response. Short-term use of a low-dose oral contraceptive does not have an effect on appetite regulation of PCOS.
CONTEXT: Ghrelin is an orexigenic peptide that stimulates food intake, whereas peptide YY (PYY) and cholecystokinin (CCK) are anorexigenic gut hormones. Patients with polycystic ovary syndrome (PCOS) appear to have alterations in appetite regulation. OBJECTIVE: We aimed to determine whether fasting or meal-stimulated ghrelin, PYY, CCK, and satiety responses are different between lean PCOSpatients and healthy women. We also aimed to assess the potential effect of oral contraceptive use on these hormones and satiety response. DESIGN AND SETTING: We conducted a prospective observational study in a university practice. PATIENTS: Eighteen lean PCOSpatients and 18 healthy control women matched for age and body mass index underwent measurements of circulating ghrelin, PYY, CCK, and satiety index (SI) before and after a standardized mixed meal at 0, 15, 30, 45, 60, 90, 120, and 180 minutes. INTERVENTIONS: For PCOSpatients who were treated with ethinyl estradiol 30 μg/drospirenone 3 mg for 3 months, measurements were repeated. MAIN OUTCOME: We measured ghrelin, PYY, and CCK levels and SI. RESULTS: At baseline, fasting ghrelin, PYY, CCK, and SI values in PCOSpatients were not different from controls. Meal-stimulated PYY, CCK, and SI were also not different between the groups, whereas PCOSpatients had significantly lower meal-stimulated ghrelin levels compared to controls (P = .04). Ghrelin, PYY, CCK, and SI did not show a significant change after treatment with ethinyl estradiol/drospirenone for 3 months. CONCLUSIONS: Basal and stimulated hunger and satiety hormones in lean PCOSpatients are not different from lean healthy women, except for a lower meal-stimulated ghrelin response. Short-term use of a low-dose oral contraceptive does not have an effect on appetite regulation of PCOS.
Authors: Pierluigi Giampaolino; Virginia Foreste; Claudia Di Filippo; Alessandra Gallo; Antonio Mercorio; Paolo Serafino; Francesco Paolo Improda; Paolo Verrazzo; Giuseppe Zara; Cira Buonfantino; Maria Borgo; Gaetano Riemma; Chiara De Angelis; Brunella Zizolfi; Giuseppe Bifulco; Luigi Della Corte Journal: Int J Mol Sci Date: 2021-02-19 Impact factor: 5.923