| Literature DB >> 24001712 |
Hai Xuan Nguyen1, Mai Thanh Thi Nguyen1, Thy Anh Nguyen1, Nhi Y Thi Nguyen1, Dao Anh Thi Phan1, Phuoc Ho Thi1, Trong Huu Phan Nguyen1, Phu Hoang Dang1, Nhan Trung Nguyen1, Jun-Ya Ueda2, Suresh Awale3.
Abstract
Three new cleistanthane diterpenes named tomocinon (1), tomocinol A (2), and tomocinol B (3), were isolated from the EtOAc extract of the seed of Caesalpinia sappan. Their structures were determined by extensive NMR spectroscopic analysis. The absolute stereochemistry of tomocinon (1) has been established by CD spectroscopic analysis. Cleistanthane diterpenes (1-3) represents the novel class of antiausterity agents having preferential cytotoxicity against PANC-1 human pancreatic cancer cell line under nutrient deprived condition with PC50 value of 34.7 μM, 42.4 μM and 39.4 μM, respectively.Entities:
Keywords: Antiausterity strategy; Anticancer drug discovery; Caesalpinia sappan; Cleistanthane diterpene; Nutrient starvation; PANC-1
Mesh：
Substances：
Year: 2013 PMID： 24001712 DOI： 10.1016/j.fitote.2013.08.018
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882