Literature DB >> 24001594

Thymoquinone: fifty years of success in the battle against cancer models.

Regine Schneider-Stock1, Isabelle H Fakhoury2, Angela M Zaki2, Chirine O El-Baba1, Hala U Gali-Muhtasib3.   

Abstract

Thymoquinone (TQ), the main active constituent of black seed essential oil, exhibits promising effects against inflammatory diseases and cancer. TQ, modulates signaling pathways that are key to cancer progression, and enhances the anticancer potential of clinical drugs while reducing their toxic side effects. Considering that TQ was isolated 50 years ago, this review focuses on TQ's chemical and pharmacological properties and the latest advances in TQ analog design and nanoformulation. We discuss our current state of knowledge of TQ's adjuvant potential and in vivo antitumor activity and highlight its ability to modulate the hallmarks of cancer.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 24001594     DOI： 10.1016/j.drudis.2013.08.021

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  49 in total

1.  Microwave-assisted extraction of Nigella sativa L. essential oil and evaluation of its antioxidant activity.

Authors:  Abdol-Samad Abedi; Marjan Rismanchi; Mehrnoush Shahdoostkhany; Abdorreza Mohammadi; Amir Mohammad Mortazavian
Journal:  J Food Sci Technol       Date:  2017-10-04       Impact factor: 2.701

2.  Molecular Biomarkers of Colorectal Cancer and Cancer Disparities: Current Status and Perspective.

Authors:  Upender Manne; Trafina Jadhav; Balananda-Dhurjati Kumar Putcha; Temesgen Samuel; Shivani Soni; Chandrakumar Shanmugam; Esther A Suswam
Journal:  Curr Colorectal Cancer Rep       Date:  2016-09-20

3.  Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer.

Authors:  Gang-Gang Mu; Ling-Li Zhang; Hong-Yan Li; Yan Liao; Hong-Gang Yu
Journal:  Dig Dis Sci       Date:  2014-10-26       Impact factor: 3.199

4.  Proteoform-Specific Protein Binding of Small Molecules in Complex Matrices.

Authors:  Geuncheol Gil; Pan Mao; Bharathi Avula; Zulfiqar Ali; Amar G Chittiboyina; Ikhlas A Khan; Larry A Walker; Daojing Wang
Journal:  ACS Chem Biol       Date:  2016-12-21       Impact factor: 5.100

5.  Solvent based optimization for extraction and stability of thymoquinone from Nigella sativa Linn. and its quantification using RP-HPLC.

Authors:  Mohammed Shariq Iqbal; Ausaf Ahmad; Brijesh Pandey
Journal:  Physiol Mol Biol Plants       Date:  2018-08-29

6.  Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway.

Authors:  Li-Min Feng; Xue-Feng Wang; Qing-Xian Huang
Journal:  J Biosci       Date:  2017-12       Impact factor: 1.826

7.  Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-κB signaling and IL-8 expression.

Authors:  Abdelkader E Ashour; Atallah F Ahmed; Ashok Kumar; Khairy M A Zoheir; Mourad A Aboul-Soud; Sheikh F Ahmad; Sabry M Attia; Adel R A Abd-Allah; Vino T Cheryan; Arun K Rishi
Journal:  Mol Cell Biochem       Date:  2016-04-15       Impact factor: 3.396

8.  Inhibition of epithelial-mesenchymal transition in bladder cancer cells via modulation of mTOR signalling.

Authors:  Banu Iskender; Kenan Izgi; Esra Hizar; Johann Jauch; Aslihan Arslanhan; Esra Hilal Yuksek; Halit Canatan
Journal:  Tumour Biol       Date:  2015-12-30

9.  Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis.

Authors:  Abdelkader E Ashour; Adel R Abd-Allah; Hesham M Korashy; Sabry M Attia; Abdelrahman Z Alzahrani; Quaiser Saquib; Saleh A Bakheet; Hala E Abdel-Hamied; Shazia Jamal; Arun K Rishi
Journal:  Mol Cell Biochem       Date:  2014-01-08       Impact factor: 3.396

10.  Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-κB.

Authors:  Lida Zhang; Yangqiu Bai; Yuxiu Yang
Journal:  Oncol Lett       Date:  2016-08-08       Impact factor: 2.967
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