Literature DB >> 24000948

Acid-degradable polymer-caged lipoplex (PCL) platform for siRNA delivery: facile cellular triggered release of siRNA.

Bong Jin Hong1, Anthony J Chipre, SonBinh T Nguyen.   

Abstract

An acid-degradable polymer-caged lipoplex (PCL) platform consisting of a cationic lipoplex core and a biocompatible, pH-responsive polymer shell has been developed for the effective delivery of small interfering RNA (siRNA) through a combination of facile loading, rapid acid-triggered release, cellular internalization, and effective endosomal escape. In vitro testing of this degradable PCL delivery platform reveals ∼45- and ∼2.5-fold enhancement of enhanced green fluorescent protein knockdown in cancer cells in comparison to either free siRNA or siRNA-loaded non-acid-degradable lipoplex formulations, respectively.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 24000948      PMCID： PMC3916954          DOI： 10.1021/ja404491r

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  29 in total

1.  Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy.

Authors:  Sang-Min Lee; Thomas V O'Halloran; SonBinh T Nguyen
Journal:  J Am Chem Soc       Date:  2010-11-15       Impact factor: 15.419

2.  Soft nanotechnology with soft nanoparticles.

Authors:  Satish Nayak; L Andrew Lyon
Journal:  Angew Chem Int Ed Engl       Date:  2005-12-02       Impact factor: 15.336

Review 3.  Synthetic, self-assembly ABCD nanoparticles; a structural paradigm for viable synthetic non-viral vectors.

Authors:  Kostas Kostarelos; Andrew D Miller
Journal:  Chem Soc Rev       Date:  2005-09-22       Impact factor: 54.564

Review 4.  Sensors and regulators of intracellular pH.

Authors:  Joseph R Casey; Sergio Grinstein; John Orlowski
Journal:  Nat Rev Mol Cell Biol       Date:  2009-12-09       Impact factor: 94.444

5.  pH-triggered nanoparticle mediated delivery of siRNA to liver cells in vitro and in vivo.

Authors:  Soumia Kolli; Suet-Ping Wong; Richard Harbottle; Brian Johnston; Maya Thanou; Andrew D Miller
Journal:  Bioconjug Chem       Date:  2013-03-07       Impact factor: 4.774

6.  Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release.

Authors:  Sang-Min Lee; Ying Song; Bong Jin Hong; Keith W MacRenaris; Daniel J Mastarone; Thomas V O'Halloran; Thomas J Meade; SonBinh T Nguyen
Journal:  Angew Chem Int Ed Engl       Date:  2010-12-17       Impact factor: 15.336

7.  Acetal-modified dextran microparticles with controlled degradation kinetics and surface functionality for gene delivery in phagocytic and non-phagocytic cells.

Authors:  Joel A Cohen; Tristan T Beaudette; Jessica L Cohen; Kyle E Broaders; Eric M Bachelder; Jean M J Fréchet
Journal:  Adv Mater       Date:  2010-08-24       Impact factor: 30.849

8.  A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo.

Authors:  Yusuke Sato; Hiroto Hatakeyama; Yu Sakurai; Mamoru Hyodo; Hidetaka Akita; Hideyoshi Harashima
Journal:  J Control Release       Date:  2012-09-20       Impact factor: 9.776

9.  Conjugation chemistry through acetals toward a dextran-based delivery system for controlled release of siRNA.

Authors:  Lina Cui; Jessica L Cohen; Crystal K Chu; Peter R Wich; Paul H Kierstead; Jean M J Fréchet
Journal:  J Am Chem Soc       Date:  2012-09-18       Impact factor: 15.419

10.  "Clickable" polymer-caged nanobins as a modular drug delivery platform.

Authors:  Sang-Min Lee; Haimei Chen; Thomas V O'Halloran; SonBinh T Nguyen
Journal:  J Am Chem Soc       Date:  2009-07-08       Impact factor: 15.419
View more
  15 in total

Review 1.  Stimuli-responsive liposomes for drug delivery.

Authors:  Y Lee; D H Thompson
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2017-02-15

2.  Direct cytosolic delivery of siRNA using nanoparticle-stabilized nanocapsules.

Authors:  Ying Jiang; Rui Tang; Bradley Duncan; Ziwen Jiang; Bo Yan; Rubul Mout; Vincent M Rotello
Journal:  Angew Chem Int Ed Engl       Date:  2014-11-12       Impact factor: 15.336

3.  Smart Nanoscale Drug Delivery Platforms from Stimuli-Responsive Polymers and Liposomes.

Authors:  Sang-Min Lee; SonBinh T Nguyen
Journal:  Macromolecules       Date:  2013-11-27       Impact factor: 5.985

4.  Substituent Effects on the pH Sensitivity of Acetals and Ketals and Their Correlation with Encapsulation Stability in Polymeric Nanogels.

Authors:  Bin Liu; S Thayumanavan
Journal:  J Am Chem Soc       Date:  2017-02-02       Impact factor: 15.419

5.  Light-mediated activation of siRNA Release in diblock copolymer assemblies for controlled gene silencing.

Authors:  Abbygail A Foster; Chad T Greco; Matthew D Green; Thomas H Epps; Millicent O Sullivan
Journal:  Adv Healthc Mater       Date:  2014-12-22       Impact factor: 9.933

Review 6.  Non-viral vectors for RNA delivery.

Authors:  Yi Yan; Xiao-Yu Liu; An Lu; Xiang-Yu Wang; Lin-Xia Jiang; Jian-Cheng Wang
Journal:  J Control Release       Date:  2022-01-10       Impact factor: 9.776

7.  Recent In Vivo Evidences of Particle-Based Delivery of Small-Interfering RNA (siRNA) into Solid Tumors.

Authors:  Yi Wen; Wilson S Meng
Journal:  J Pharm Innov       Date:  2014-06-01       Impact factor: 2.750

8.  Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles.

Authors:  Adrian T Press; Anja Traeger; Christian Pietsch; Alexander Mosig; Michael Wagner; Mark G Clemens; Nayla Jbeily; Nicole Koch; Michael Gottschaldt; Nicolas Bézière; Volodymyr Ermolayev; Vasilis Ntziachristos; Jürgen Popp; Michael M Kessels; Britta Qualmann; Ulrich S Schubert; Michael Bauer
Journal:  Nat Commun       Date:  2014-12-03       Impact factor: 14.919

9.  Zwitterionic poly(carboxybetaine)-based cationic liposomes for effective delivery of small interfering RNA therapeutics without accelerated blood clearance phenomenon.

Authors:  Yan Li; Ruiyuan Liu; Yuanjie Shi; Zhenzhong Zhang; Xin Zhang
Journal:  Theranostics       Date:  2015-02-27       Impact factor: 11.556

10.  Folate receptor-targeted liposomes loaded with a diacid metabolite of norcantharidin enhance antitumor potency for H22 hepatocellular carcinoma both in vitro and in vivo.

Authors:  Min-Chen Liu; Lin Liu; Xia-Rong Wang; Wu-Ping Shuai; Ying Hu; Min Han; Jian-Qing Gao
Journal:  Int J Nanomedicine       Date:  2016-04-04
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.