Michael Strupp1, Marianne Dieterich, Thomas Brandt. 1. Department of Neurology and German Center for Vertigo and Balance Disorders (IFB), Institute for Clinical Neurosciences, Ludwig-Maximilians University of Munich, Klinikum Großhadern, Germany. Michael.Strupp@med.uni-muenchen.de
Abstract
BACKGROUND: Recent studies have extended our understanding of the pathophysiology, natural course, and treatment of vestibular vertigo. The relative frequency of the different forms is as follows: benign paroxysmal positional vertigo (BPPV) 17.1%; phobic vestibular vertigo 15%; central vestibular syndromes 12.3%; vestibular migraine 11.4%; Menière's disease 10.1%; vestibular neuritis 8.3%; bilateral vestibulopathy 7.1%; vestibular paroxysmia 3.7%. METHODS: Selective literature survey with particular regard to Cochrane reviews and the guidelines of the German Neurological Society. RESULTS: In more than 95% of cases BPPV can be successfully treated by means of liberatory maneuvers (controlled studies); the long-term recurrence rate is 50%. Corticosteroids improve recovery from acute vestibular neuritis (one controlled, several noncontrolled studies); the risk of recurrence is 2-12%. A newly identified subtype of bilateral vestibulopathy, termed cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS), shows no essential improvement in the long term. Long-term high-dose treatment with betahistine is probably effective against Menière's disease (noncontrolled studies); the frequency of episodes decreases spontaneously in the course of time (> 5 years). The treatment of choice for vestibular paroxysmia is carbamazepine (noncontrolled study). Aminopyridine, chlorzoxazone, and acetyl-DL-leucine are new treatment options for various cerebellar diseases. CONCLUSION: Most vestibular syndromes can be treated successfully. The efficacy of treatments for Menière's disease, vestibular paroxysmia, and vestibular migraine requires further research.
BACKGROUND: Recent studies have extended our understanding of the pathophysiology, natural course, and treatment of vestibular vertigo. The relative frequency of the different forms is as follows: benign paroxysmal positional vertigo (BPPV) 17.1%; phobic vestibular vertigo 15%; central vestibular syndromes 12.3%; vestibular migraine 11.4%; Menière's disease 10.1%; vestibular neuritis 8.3%; bilateral vestibulopathy 7.1%; vestibular paroxysmia 3.7%. METHODS: Selective literature survey with particular regard to Cochrane reviews and the guidelines of the German Neurological Society. RESULTS: In more than 95% of cases BPPV can be successfully treated by means of liberatory maneuvers (controlled studies); the long-term recurrence rate is 50%. Corticosteroids improve recovery from acute vestibular neuritis (one controlled, several noncontrolled studies); the risk of recurrence is 2-12%. A newly identified subtype of bilateral vestibulopathy, termed cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS), shows no essential improvement in the long term. Long-term high-dose treatment with betahistine is probably effective against Menière's disease (noncontrolled studies); the frequency of episodes decreases spontaneously in the course of time (> 5 years). The treatment of choice for vestibular paroxysmia is carbamazepine (noncontrolled study). Aminopyridine, chlorzoxazone, and acetyl-DL-leucine are new treatment options for various cerebellar diseases. CONCLUSION: Most vestibular syndromes can be treated successfully. The efficacy of treatments for Menière's disease, vestibular paroxysmia, and vestibular migraine requires further research.
Authors: Marco Antonio Garduño-Anaya; Heloísa Couthino De Toledo; Ramón Hinojosa-González; Carlo Pane-Pianese; Luis Camilo Ríos-Castañeda Journal: Otolaryngol Head Neck Surg Date: 2005-08 Impact factor: 3.497
Authors: Michael Strupp; Katharina Hüfner; Ruth Sandmann; Andreas Zwergal; Marianne Dieterich; Klaus Jahn; Thomas Brandt Journal: Dtsch Arztebl Int Date: 2011-03-25 Impact factor: 5.594
Authors: Klaus Jahn; Reto W Kressig; Stephanie A Bridenbaugh; Thomas Brandt; Roman Schniepp Journal: Dtsch Arztebl Int Date: 2015-06-05 Impact factor: 5.594