Mohammad Hashemi1, Zahra Zakeri2, Ebrahim Eskandari-Nasab3, Mahdi Atabaki4, Seyed Mohammad Ebrahim Pourhosseini1, Mehdi Jahantigh5, Gholamreza Bahari2, Mohsen Taheri6. 1. Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. 2. Dept. of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. 3. Dept. of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. 4. Dept. of Immunology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. 5. Dept. of Pathology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. 6. Genetics of Non communicable Disease research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Abstract
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. The aim of the present study was to investigate the impact of CD226 rs727088 and rs763361 polymorphisms and susceptibility to RA in a sample of the Iranian population. METHODS: This case-control study was carried out on 100 patients with RA and 104 healthy subjects. The polymorphisms were determined using tetra amplification refractory mutation system-polymerase chain reaction assay. RESULTS: The rs763361 (Gly307Ser) polymorphism increased the risk of RA in codominant, dominant and recessive-tested inheritance models (odds ratio [OR] = 3.18, 95% confidence intervals [95% CI] = 1.44-7.02, P = 0.004, CC vs. TT, and OR = 1.98, 95% CI = 1.10-3.57, P = 0.023, CC vs. CT-TT, and OR = 2.61, 95% CI = 1.26-5.37, P = 0.010, CC + CT vs. TT, respectively). In addition, the rs763361 T allele increased the risk of RA (OR = 2.06, 95% CI = 1.38-3.08, P<0.001). However, no significant difference was observed among the groups regarding CD226 rs727088 polymorphism (χ2 = 3.20, P = 0.202). CONCLUSIONS: Our finding showed that CD226 rs763361, but not rs727088, gene polymorphism increased the risk of RA in a sample of the Iranian population.
BACKGROUND:Rheumatoid arthritis (RA) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. The aim of the present study was to investigate the impact of CD226rs727088 and rs763361 polymorphisms and susceptibility to RA in a sample of the Iranian population. METHODS: This case-control study was carried out on 100 patients with RA and 104 healthy subjects. The polymorphisms were determined using tetra amplification refractory mutation system-polymerase chain reaction assay. RESULTS: The rs763361 (Gly307Ser) polymorphism increased the risk of RA in codominant, dominant and recessive-tested inheritance models (odds ratio [OR] = 3.18, 95% confidence intervals [95% CI] = 1.44-7.02, P = 0.004, CC vs. TT, and OR = 1.98, 95% CI = 1.10-3.57, P = 0.023, CC vs. CT-TT, and OR = 2.61, 95% CI = 1.26-5.37, P = 0.010, CC + CT vs. TT, respectively). In addition, the rs763361 T allele increased the risk of RA (OR = 2.06, 95% CI = 1.38-3.08, P<0.001). However, no significant difference was observed among the groups regarding CD226rs727088 polymorphism (χ2 = 3.20, P = 0.202). CONCLUSIONS: Our finding showed that CD226rs763361, but not rs727088, gene polymorphism increased the risk of RA in a sample of the Iranian population.
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