BACKGROUND: Epidemiological data suggest a role for common viruses in the pathogenesis of multiple sclerosis (MS), and recent data showed a negative association of past cytomegalovirus (CMV) infection on pediatric MS risk. OBJECTIVE: Our aim was to analyze the association of CMV infection with MS risk in an adult case-control material. A meta-analysis was performed to validate our findings. METHODS: Epidemiological Investigation in MS (EIMS) is a case-control study with incident cases and population-based controls. Anti-CMV antibody titers were measured with ELISA, and HLA-A and DRB1 genotyping was performed with SSP-PCR, in 658 MS cases, who all fulfilled the McDonald criteria for MS, and 786 controls. RESULTS: CMV seropositivity was associated with a decreased MS risk, OR = 0.73 (0.58-0.92 95% CI), p = 0.005, adjusted for index age, gender, smoking, sun exposure, EBNA1 IgG titer and HLA-A*02 and DRB1*15. When we removed all cases and controls younger than 18 years at index, the protective effect was still apparent. CONCLUSIONS: CMV is negatively associated with adult-onset MS pathology, consistent with results from a study on pediatric MS cases. It remains to be shown whether this negative association is due to a true protective effect of CMV infection on MS risk.
BACKGROUND: Epidemiological data suggest a role for common viruses in the pathogenesis of multiple sclerosis (MS), and recent data showed a negative association of past cytomegalovirus (CMV) infection on pediatric MS risk. OBJECTIVE: Our aim was to analyze the association of CMV infection with MS risk in an adult case-control material. A meta-analysis was performed to validate our findings. METHODS: Epidemiological Investigation in MS (EIMS) is a case-control study with incident cases and population-based controls. Anti-CMV antibody titers were measured with ELISA, and HLA-A and DRB1 genotyping was performed with SSP-PCR, in 658 MS cases, who all fulfilled the McDonald criteria for MS, and 786 controls. RESULTS: CMV seropositivity was associated with a decreased MS risk, OR = 0.73 (0.58-0.92 95% CI), p = 0.005, adjusted for index age, gender, smoking, sun exposure, EBNA1 IgG titer and HLA-A*02 and DRB1*15. When we removed all cases and controls younger than 18 years at index, the protective effect was still apparent. CONCLUSIONS: CMV is negatively associated with adult-onset MS pathology, consistent with results from a study on pediatric MS cases. It remains to be shown whether this negative association is due to a true protective effect of CMV infection on MS risk.
Authors: Jennifer Graves; Siri Grandhe; Kelley Weinfurtner; Lauren Krupp; Anita Belman; Tanuja Chitnis; Jayne Ness; Bianca Weinstock-Guttman; Mark Gorman; Marc Patterson; Moses Rodriguez; Tim Lotze; Gregory Aaen; Ellen M Mowry; John W Rose; Timothy Simmons; T Charles Casper; Judith James; Emmanuelle Waubant Journal: Neurology Date: 2014-10-22 Impact factor: 9.910
Authors: A Gyllenberg; F Piehl; L Alfredsson; J Hillert; I L Bomfim; L Padyukov; M Orho-Melander; E Lindholm; M Landin-Olsson; Å Lernmark; T Olsson; I Kockum Journal: Genes Immun Date: 2014-01-16 Impact factor: 2.676
Authors: Annette Langer-Gould; Jun Wu; Robyn Lucas; Jessica Smith; Edlin Gonzales; Lilyana Amezcua; Samantha Haraszti; Lie Hong Chen; Hong Quach; Judith A James; Lisa F Barcellos; Anny H Xiang Journal: Neurology Date: 2017-08-30 Impact factor: 9.910
Authors: Marie Wunsch; Christopher Hohmann; Bianca Milles; Christina Rostermund; Paul V Lehmann; Michael Schroeter; Antonios Bayas; Jochen Ulzheimer; Mathias Mäurer; Süleyman Ergün; Stefanie Kuerten Journal: Viruses Date: 2016-04-23 Impact factor: 5.048