| Literature DB >> 23999392 |
Erik A Teunissen1, Markus de Raad1, Enrico Mastrobattista2.
Abstract
Virus-like particles (VLPs), aggregates of capsid proteins devoid of viral genetic material, show great promise in the fields of vaccine development and gene therapy. These particles spontaneously self-assemble after heterologous expression of viral structural proteins. This review will focus on the use of virus-like particles derived from polyomavirus capsid proteins. Since their first recombinant production 27 years ago these particles have been investigated for a myriad of biomedical applications. These virus-like particles are safe, easy to produce, can be loaded with a broad range of diverse cargoes and can be tailored for specific delivery or epitope presentation. We will highlight the structural characteristics of polyomavirus-derived VLPs and give an overview of their applications in diagnostics, vaccine development and gene delivery.Entities:
Keywords: AFFFF; APyV; BK virus; BKPyV; CTL; ChPyV; DC; DHFR; DIVA; DTT; E. coli; EDTA; EGFP; EGTA; ER; Escherichia coli; FPyV; GCV; GHPyV; GRAS; GST; Gene delivery; Gene therapy; HPV; HaPyV; JC virus; JCPyV; LCMV; LPyV; MALS; MCC; MCPyV; MPtV; MPyV; Merkel cell carcinoma; Merkel cell polyomavirus; NLS; NP; NTA; OVA; PBS; PLP; PNA; PSA; PTX; PUUV; Polyomavirus; Pseudovirion; Puumala hantavirus; PyV; S. cerevisiae; SR101; SV40; Saccharomyces cerevisiae; Sf; Spodoptera frugiperda; TEM; VLP; Vaccine; Virus-like particle; aa; amino acid; asymmetrical-flow field flow fractionation; avian polyomavirus; base pair; beta-lymphotropic polyomavirus; bp; chimpanzee polyomavirus; cytotoxic T lymphocyte; dendritic cell; differentiate infected from vaccinated animals; dihydrofolate reductase; dithiothreitol; double-stranded DNA; dsDNA; endoplasmic reticulum; enhanced green fluorescent protein; ethylene glycol tetraacetic acid; ethylenediaminetetraacetic acid; finch polyomavirus; ganciclovir; generally recognized as safe; glutathione S-transferase; goose hemorrhagic polyomavirus; hEGF; hamster polyomavirus; human epidermal growth factor; human papillomavirus; lymphocytic choriomeningitis virus; multiple-angle light scattering; murine pneumotropic virus; murine polyomavirus; nitrilotriacetic acid; nuclear localization signal; nucleocapsid protein; ovalbumin; paclitaxel; peptide nucleic acids; phosphate buffered saline; polyoma-like particle; polyomavirus; prostate specific antigen; simian virus 40; sulforhodamine 101; transmission electron microscopy; virus-like particle
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Year: 2013 PMID： 23999392 DOI： 10.1016/j.jconrel.2013.08.026
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776