[Secondary osteoporosis or secondary contributors to bone loss in fracture. Bone metabolic disorders in patients with diabetes mellitus].

Several clinical studies including two meta-analyses revealed that patients with diabetes mellitus have an elevated fracture risk compared to non-diabetic subjects, suggesting that diabetes mellitus is a underlying illness for secondary osteoporosis. The fracture risk observed in these patients was higher than those expected by BMD, indicating that bone fragility in these patients may be caused by poor bone such as excessively glycated bone collagen, low bone turnover, thinner cortical thickness, and increased cortical porosity. Diabetic osteoporosis may be one of most common disease in secondary osteoporosis. Large scale observation and prevention studies for fracture are needed to establish diagnostic criterion and standard treatment for diabetic osteoporosis.