Literature DB >> 2399843

31 phosphorous nuclear magnetic resonance spectroscopy of rat brain with temporary global cerebral ischemia--methodology.

O Haraldseth1, T Southon, T Grønås, P Jynge, S E Gisvold, G Unsgård.   

Abstract

31 P Magnetic Resonance Spectroscopy offers a technique for measuring intracellular pH and the high energy phosphates Phosphocreatine (PCr) and ATP in vivo. The 2-vessel occlusion model of temporary global cerebral ischaemia in the rat was adopted in this technique. This approach gave reliable results for intracellular pH and valuable information about PCr and ATP with an accurate time resolution for the changes during ischaemia and early reperfusion. The method may be a useful tool to evaluate possible benefits from different kinds of pre- and post ischaemic drug intervention.

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Year:  1990        PMID： 2399843     DOI： 10.1007/bf01407523

Source DB:  PubMed          Journal:  Acta Neurochir (Wien)        ISSN： 0001-6268            Impact factor:   2.216


  23 in total

1.  Effect of allopurinol on ischemia and reperfusion-induced cerebral injury in spontaneously hypertensive rats.

Authors:  T Itoh; M Kawakami; Y Yamauchi; S Shimizu; M Nakamura
Journal:  Stroke       Date:  1986 Nov-Dec       Impact factor: 7.914

2.  An approach to the problem of metabolic heterogeneity in brain: ischemia and reflow after ischemia.

Authors:  B Chance; J S Leigh; S Nioka; T Sinwell; D Younkin; D S Smith
Journal:  Ann N Y Acad Sci       Date:  1987       Impact factor: 5.691

3.  A new model of bilateral hemispheric ischemia in the unanesthetized rat.

Authors:  W A Pulsinelli; J B Brierley
Journal:  Stroke       Date:  1979 May-Jun       Impact factor: 7.914

4.  Changes in extra- and intracellular pH in the brain during and following ischemia in hyperglycemic and in moderately hypoglycemic rats.

Authors:  M L Smith; R von Hanwehr; B K Siesjö
Journal:  J Cereb Blood Flow Metab       Date:  1986-10       Impact factor: 6.200

5.  Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model.

Authors:  M L Smith; G Bendek; N Dahlgren; I Rosén; T Wieloch; B K Siesjö
Journal:  Acta Neurol Scand       Date:  1984-06       Impact factor: 3.209

6.  Models for studying long-term recovery following forebrain ischemia in the rat. 1. Circulatory and functional effects of 4-vessel occlusion.

Authors:  P Blomqvist; H Mabe; M Ingvar; B K Siesjö
Journal:  Acta Neurol Scand       Date:  1984-06       Impact factor: 3.209

7.  Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. I. Methodology.

Authors:  D G Gadian; R S Frackowiak; H A Crockard; E Proctor; K Allen; S R Williams; R W Russell
Journal:  J Cereb Blood Flow Metab       Date:  1987-04       Impact factor: 6.200

8.  Measurements of in vivo energy metabolism in experimental cerebral ischaemia using 31P-NMR for the evaluation of protective effects of perfluorochemicals and glycerol.

Authors:  S Naruse; Y Horikawa; C Tanaka; K Hirakawa; H Nishikawa; H Watari
Journal:  Neurol Res       Date:  1984-12       Impact factor: 2.448

9.  In vivo studies of energy metabolism in experimental cerebral ischemia using topical magnetic resonance. Changes in 31P-nuclear magnetic resonance spectra compared with electroencephalograms and regional cerebral blood flow.

Authors:  Y Horikawa; S Naruse; K Hirakawa; C Tanaka; H Nishikawa; H Watari
Journal:  J Cereb Blood Flow Metab       Date:  1985-06       Impact factor: 6.200

10.  Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury.

Authors:  R Busto; W D Dietrich; M Y Globus; I Valdés; P Scheinberg; M D Ginsberg
Journal:  J Cereb Blood Flow Metab       Date:  1987-12       Impact factor: 6.200
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  2 in total

1.  The NMDA antagonist MK-801 improved metabolic recovery after 10 minutes global cerebral ischaemia in rats measured with 31 phosphorous magnetic resonance spectroscopy.

Authors:  O Haraldseth; T Grønås; T E Southon; P Jynge; S E Gisvold; G Unsgård
Journal:  Acta Neurochir (Wien)       Date:  1990       Impact factor: 2.216

2.  Hemodilution with liposome-encapsulated low-oxygen-affinity hemoglobin does not attenuate hypothermic cerebral ischemia in rats.

Authors:  Teiji Oda; Tetsuhiro Kimura; Yoshitaka Ogata; Yutaka Fujise
Journal:  J Artif Organs       Date:  2005       Impact factor: 1.385
  2 in total

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