Literature DB >> 23998078

The Prevalence of the Beta Thalassemia Trait among the Pregnant Women who attended the ANC Clinic in a PHC, by using the NESTROF Test in Bangalore, Karnataka.

Praveen Kulkarni1, N R Ramesh Masthi, Sr Niveditha, R Suvarna.   

Abstract

UNLABELLED: Contaxt: Every year in India 6000 to 8000 children are born with thalassaemia major. The birth of such a child produces considerable physical and economic strain on the affected child, its family and the community at large. Thus, the emphasis must shift from the treatment to the prevention of such births in the future. AIMS: To find out the prevalence of the Beta Thalassaemia trait among the pregnant women who attended the antenatal clinics in a Primary Health Centre, by using the NESTROF test; to describe the socio-demographic characteristics of the study subjects, to find out the pregnancies which were 'at risk' of delivering babies with Thalassaemia major and to find out the 'awareness' of the pregnant women regarding Thalassaemia.
MATERIAL AND METHODS: This exploratory study was conducted in a PHC which was attached to the Department of Community Medicine of a medical college which was situated in Bangalore, India, for a period of 3 months. All the pregnant women who attended the antenatal clinic and the husbands of the NESTROF positive women were included in the study. The details regarding the sociodemographic characteristics of the women were collected on a structured proforma and the NESTROF test was performed.
RESULTS: Out of the 210 pregnant women who were tested, 18 (8.5%) were thalassaemia carriers. 12 (66.6%) of them were between 20 - 25 years of age. 5 (27.7%) were born out of 2(nd) degree consanguineous marriages. 7 (38.8%) had a history of abortions, among which 6 (33.3%) were in the 1(st) trimesters of their pregnancies. Out of the 18 positive women, 9 (50%) had turned up with their husbands. All of the husbands were negative for the Thalassaemia carrier status. Thus, there was no pregnancy which was at a risk of delivering babies with thalassaemia major. None (100%) of the pregnant women were aware of the disease, thalassaemia.
CONCLUSIONS: The prevalence of the Beta Thalassaemia trait among the pregnant women was 8.5%.

Entities:  

Keywords:  Awareness; Beta Thalassaemia trait; Prenatal diagnosis; Thalassaemia major; the NESTROF test

Year:  2013        PMID: 23998078      PMCID: PMC3749648          DOI: 10.7860/JCDR/2013/5286.3149

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  8 in total

Review 1.  Carrier screening and prenatal diagnosis of beta-thalassemia.

Authors:  M Maheshwari; S Arora; M Kabra; P S Menon
Journal:  Indian Pediatr       Date:  1999-11       Impact factor: 1.411

2.  NESTROFT: a screening test for beta thalassemia trait.

Authors:  B C Mehta
Journal:  Indian J Med Sci       Date:  2002-11

3.  Prevalence and some epidemiological factors of beta thalassaemia trait in Sindhi community of Nagpur City, India.

Authors:  Deepa V Mulchandani; M B Fulare; S P Zodpey; N D Vasudeo
Journal:  Indian J Public Health       Date:  2008 Jan-Mar

4.  Regional and ethnic distribution of beta thalassemia mutations and effect of consanguinity in patients referred for prenatal diagnosis.

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Journal:  J Coll Physicians Surg Pak       Date:  2007-03       Impact factor: 0.711

5.  Validity of Nestroft in screening and diagnosis of beta-thalassemia trait.

Authors:  S Gomber; N Madan
Journal:  J Trop Pediatr       Date:  1997-12       Impact factor: 1.165

6.  'NESTROFT'--an effective screening test for beta thalassemia trait.

Authors:  M Manglani; M R Lokeshwar; V G Vani; N Bhatia; V Mhaskar
Journal:  Indian Pediatr       Date:  1997-08       Impact factor: 1.411

7.  Feasibility of introducing genetic services in the National Family Welfare Programme in India.

Authors:  Reeta Rasaily
Journal:  Indian J Med Res       Date:  2009-10       Impact factor: 2.375

8.  NESTROFF as a screening test for detection of Beta-thalassemia trait.

Authors:  S K Bobhate; S T Gaikwad; T Bhaledrao
Journal:  Indian J Pathol Microbiol       Date:  2002-07       Impact factor: 0.740

  8 in total
  3 in total

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Authors:  Amanpreet Sundh; Paramjit Kaur; Anshu Palta; Gagandeep Kaur
Journal:  Blood Res       Date:  2020-09-30

2.  High prevalence of thalassemia in migrant populations in Guangdong Province, China.

Authors:  Bing Li; Xiao-zhuang Zhang; Ai-hua Yin; Qing-guo Zhao; Li Wu; Yuan-zhu Ma; Ming-yong Luo; Shou-yi Yu
Journal:  BMC Public Health       Date:  2014-09-02       Impact factor: 3.295

3.  NESTROFT-A Cost-Effective Mass Screening Tool for the Detection of β-Thalassemia Carrier Status in Anemic Pregnant Women: A Step Toward Reducing the National Disease Burden.

Authors:  Manasi Gosavi; Ramesh Chavan; M B Bellad
Journal:  J Lab Physicians       Date:  2021-07-09
  3 in total

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