BACKGROUND: Serum γ-glutamyltranspeptidase (GGT), a marker of fatty liver disease (FLD), predicts mortality in young adults. However, the association between serum GGT and mortality in older adults is unclear. OBJECTIVES: To examine if elevated serum GGT predicts all-cause, cardiovascular (CVD), and liver mortality in community-dwelling older adults. DESIGN AND SETTING: A prospective cohort study including 2364 participants (mean-age 70 yr, BMI-24.5 kg/m2, 54% women) from the Rancho Bernardo Study who attended a research visit in 1984-87 when multiple metabolic covariates were ascertained including serum GGT. They were followed for a mean (± standard deviation) of 13.7 (±6.2) years. MEASUREMENT: Multivariable-adjusted Cox-proportional hazards analyses were conducted to examine the association between elevated serum GGT (>51 U/L in men and > 33 U/L in women) and all-cause, CVD, and liver mortality. RESULTS: In these older men and women, cumulative mortality was 56.2% (n=1329) with CVD and liver mortality accounting for 49.4% and 2.3% of all deaths, respectively, over 32,387 person-years of follow-up. In multivariate analyses (adjusted for age, sex, alcohol use, body-mass-index, total cholesterol, HDL cholesterol, serum triglyceride, smoking status, systolic blood pressure, diabetes mellitus, serum interleukin-6, and c-reactive protein), serum GGT elevation was significantly associated with all-cause (HR, 1.55, 95% CI, 1.21-1.98), CVD (HR, 1.51, 95% CI, 1.04-2.17), and liver mortality (HR, 9.10, 95% CI, 3.42-24.26). CONCLUSIONS: In community-dwelling older adults, serum GGT is an independent predictor of all-cause, CVD, and liver mortality.
BACKGROUND: Serum γ-glutamyltranspeptidase (GGT), a marker of fatty liver disease (FLD), predicts mortality in young adults. However, the association between serum GGT and mortality in older adults is unclear. OBJECTIVES: To examine if elevated serum GGT predicts all-cause, cardiovascular (CVD), and liver mortality in community-dwelling older adults. DESIGN AND SETTING: A prospective cohort study including 2364 participants (mean-age 70 yr, BMI-24.5 kg/m2, 54% women) from the Rancho Bernardo Study who attended a research visit in 1984-87 when multiple metabolic covariates were ascertained including serum GGT. They were followed for a mean (± standard deviation) of 13.7 (±6.2) years. MEASUREMENT: Multivariable-adjusted Cox-proportional hazards analyses were conducted to examine the association between elevated serum GGT (>51 U/L in men and > 33 U/L in women) and all-cause, CVD, and liver mortality. RESULTS: In these older men and women, cumulative mortality was 56.2% (n=1329) with CVD and liver mortality accounting for 49.4% and 2.3% of all deaths, respectively, over 32,387 person-years of follow-up. In multivariate analyses (adjusted for age, sex, alcohol use, body-mass-index, total cholesterol, HDL cholesterol, serum triglyceride, smoking status, systolic blood pressure, diabetes mellitus, serum interleukin-6, and c-reactive protein), serum GGT elevation was significantly associated with all-cause (HR, 1.55, 95% CI, 1.21-1.98), CVD (HR, 1.51, 95% CI, 1.04-2.17), and liver mortality (HR, 9.10, 95% CI, 3.42-24.26). CONCLUSIONS: In community-dwelling older adults, serum GGT is an independent predictor of all-cause, CVD, and liver mortality.
Authors: Diewertje Sluik; Joline W J Beulens; Cornelia Weikert; Susan van Dieren; Annemieke M W Spijkerman; Daphne L van der A; Andreas Fritsche; Hans-Georg Joost; Heiner Boeing; Ute Nöthlings Journal: Diabetes Metab Res Rev Date: 2012-03 Impact factor: 4.876
Authors: Douglas S Lee; Jane C Evans; Sander J Robins; Peter W Wilson; Irene Albano; Caroline S Fox; Thomas J Wang; Emelia J Benjamin; Ralph B D'Agostino; Ramachandran S Vasan Journal: Arterioscler Thromb Vasc Biol Date: 2006-11-09 Impact factor: 8.311
Authors: Christopher C Patterson; Stefan Blankenberg; Yoav Ben-Shlomo; Luke Heslop; Antony Bayer; Gordon Lowe; Tanja Zeller; John Gallacher; Ian Young; John Yarnell Journal: Int J Cardiol Date: 2015-08-05 Impact factor: 4.164
Authors: Shozab S Ali; Ebenezer T Oni; Michael J Blaha; Emir Veledar; Hamid R Feiz; Theodore Feldman; Arthur S Agatston; Roger S Blumenthal; Raquel D Conceicao; Jose A M Carvalho; Raul D Santos; Khurram Nasir Journal: Nutr Metab (Lond) Date: 2016-05-18 Impact factor: 4.169