A A Abou-Bakr1, A Elbasmi. 1. Dr. Amany A. Abou-Bakr, Associate Professor, Department of Pathology, National Cancer Institute, Cairo University, Egypt. Email: amany_aboubakr@hotmail.com Tel. +965-66267300.
Abstract
BACKGROUND: There is a need for informative molecular markers that provide prognostic information over and above that given by conventional pathologic parameters. This study examined the expression and potential prognostic value of c-MET in colorectal adenocarcinoma. MATERIAL AND METHODS: Two-hundred and thirty cases were evaluable after tissue microarray construction and evaluated for c-MET expression by immunohistochemistry. The results were correlated with standard clinicopathologic prognostic factors. Cases were followed up for 5 years. RESULTS: c-MET was highly expressed in 138 of 230 cases (60%). In normal tissues a negative or weak reaction was observed. Significantly higher c-MET expression was found in the metastatic group (p=0.04). No significant association was found in relation to age, sex, tumor site, tumor size, histological type, or tumor grade (p > 0.05). The 5-year disease free survival for patients with low levels of expression was significantly higher than that for patients with high levels (64% versus 45%, p=0.04). CONCLUSION: c-MET seems to be a valuable biomarker in colorectal adenocarcinoma; overexpression is a useful prognostic indicator for metastasis and patient outcome. KEYWORDS: c-MET, prognosis, colorectal adenocarcinoma, tissue microarray.
BACKGROUND: There is a need for informative molecular markers that provide prognostic information over and above that given by conventional pathologic parameters. This study examined the expression and potential prognostic value of c-MET in colorectal adenocarcinoma. MATERIAL AND METHODS: Two-hundred and thirty cases were evaluable after tissue microarray construction and evaluated for c-MET expression by immunohistochemistry. The results were correlated with standard clinicopathologic prognostic factors. Cases were followed up for 5 years. RESULTS:c-MET was highly expressed in 138 of 230 cases (60%). In normal tissues a negative or weak reaction was observed. Significantly higher c-MET expression was found in the metastatic group (p=0.04). No significant association was found in relation to age, sex, tumor site, tumor size, histological type, or tumor grade (p > 0.05). The 5-year disease free survival for patients with low levels of expression was significantly higher than that for patients with high levels (64% versus 45%, p=0.04). CONCLUSION:c-MET seems to be a valuable biomarker in colorectal adenocarcinoma; overexpression is a useful prognostic indicator for metastasis and patient outcome. KEYWORDS: c-MET, prognosis, colorectal adenocarcinoma, tissue microarray.
Authors: Cathy Eng; Alberto Bessudo; Lowell L Hart; Aleksey Severtsev; Oleg Gladkov; Lothar Müller; Mikhail V Kopp; Vladimir Vladimirov; Robert Langdon; Bogdan Kotiv; Sandro Barni; Ching Hsu; Ellen Bolotin; Reinhard von Roemeling; Brian Schwartz; Johanna C Bendell Journal: Int J Cancer Date: 2016-03-22 Impact factor: 7.396