Why do migraines often decrease as we age?

Migraine undergoes both an evolving state in the formative years but also has a remitting state which bears resemblance to the former. Underlying genetics may contribute to the initiating sequence for these processes but the patient's lifetime environment may influence the expression of the disease. Systems rarely thought of in terms of neurologic disease such as the inflammatory system may have significant contributions to modulating this process and accounting for the clinical presentation of migraine.