Literature DB >> 23995255

TALENoffer: genome-wide TALEN off-target prediction.

Jan Grau1, Jens Boch, Stefan Posch.   

Abstract

SUMMARY: Transcription activator-like effector nucleases (TALENs) have become an accepted tool for targeted mutagenesis, but undesired off-targets remain an important issue. We present TALENoffer, a novel tool for the genome-wide prediction of TALEN off-targets. We show that TALENoffer successfully predicts known off-targets of engineered TALENs and yields a competitive runtime, scanning complete mammalian genomes within a few minutes. AVAILABILITY: TALENoffer is available as a command line program from http://www.jstacs.de/index.php/TALENoffer and as a Galaxy server at http://galaxy.informatik.uni-halle.de. CONTACT: grau@informatik.uni-halle.de

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Year:  2013        PMID： 23995255     DOI： 10.1093/bioinformatics/btt501

Source DB:  PubMed          Journal:  Bioinformatics        ISSN： 1367-4803            Impact factor:   6.937


  39 in total

Review 1.  Tools for TAL effector design and target prediction.

Authors:  Nicholas J Booher; Adam J Bogdanove
Journal:  Methods       Date:  2014-06-27       Impact factor: 3.608

2.  Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys.

Authors:  Yongchang Chen; Juehua Yu; Yuyu Niu; Dongdong Qin; Hailiang Liu; Gang Li; Yingzhou Hu; Jiaojian Wang; Yi Lu; Yu Kang; Yong Jiang; Kunhua Wu; Siguang Li; Jingkuan Wei; Jing He; Junbang Wang; Xiaojing Liu; Yuping Luo; Chenyang Si; Raoxian Bai; Kunshan Zhang; Jie Liu; Shaoyong Huang; Zhenzhen Chen; Shuang Wang; Xiaoying Chen; Xinhua Bao; Qingping Zhang; Fuxing Li; Rui Geng; Aibin Liang; Dinggang Shen; Tianzi Jiang; Xintian Hu; Yuanye Ma; Weizhi Ji; Yi Eve Sun
Journal:  Cell       Date:  2017-05-18       Impact factor: 41.582

Review 3.  TALEN-mediated genome engineering to generate targeted mice.

Authors:  Daniel Sommer; Annika E Peters; Ann-Kathrin Baumgart; Marc Beyer
Journal:  Chromosome Res       Date:  2015-02       Impact factor: 5.239

4.  TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy.

Authors:  Zheng Hu; Wencheng Ding; Da Zhu; Lan Yu; Xiaohui Jiang; Xiaoli Wang; Changlin Zhang; Liming Wang; Teng Ji; Dan Liu; Dan He; Xi Xia; Tao Zhu; Juncheng Wei; Peng Wu; Changyu Wang; Ling Xi; Qinglei Gao; Gang Chen; Rong Liu; Kezhen Li; Shuang Li; Shixuan Wang; Jianfeng Zhou; Ding Ma; Hui Wang
Journal:  J Clin Invest       Date:  2014-12-15       Impact factor: 14.808

5.  A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

Authors:  Luke M Judge; Juan A Perez-Bermejo; Annie Truong; Alexandre Js Ribeiro; Jennie C Yoo; Christina L Jensen; Mohammad A Mandegar; Nathaniel Huebsch; Robyn M Kaake; Po-Lin So; Deepak Srivastava; Beth L Pruitt; Nevan J Krogan; Bruce R Conklin
Journal:  JCI Insight       Date:  2017-07-20

6.  TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys.

Authors:  Hailiang Liu; Yongchang Chen; Yuyu Niu; Kunshan Zhang; Yu Kang; Weihong Ge; Xiaojing Liu; Enfeng Zhao; Chencheng Wang; Shaoyun Lin; Bo Jing; Chenyang Si; Quan Lin; Xiaoying Chen; Haijun Lin; Xiuqiong Pu; Yingying Wang; Binlian Qin; Fang Wang; Hong Wang; Wei Si; Jing Zhou; Tao Tan; Tianqing Li; Shaohui Ji; Zhigang Xue; Yuping Luo; Liming Cheng; Qi Zhou; Siguang Li; Yi Eve Sun; Weizhi Ji
Journal:  Cell Stem Cell       Date:  2014-02-13       Impact factor: 24.633

7.  Targeted Disruption of the β2-Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells.

Authors:  Dachun Wang; Yuan Quan; Qing Yan; John E Morales; Rick A Wetsel
Journal:  Stem Cells Transl Med       Date:  2015-08-18       Impact factor: 6.940

8.  Interspecies organogenesis generates autologous functional islets.

Authors:  Tomoyuki Yamaguchi; Hideyuki Sato; Megumi Kato-Itoh; Teppei Goto; Hiromasa Hara; Makoto Sanbo; Naoaki Mizuno; Toshihiro Kobayashi; Ayaka Yanagida; Ayumi Umino; Yasunori Ota; Sanae Hamanaka; Hideki Masaki; Sheikh Tamir Rashid; Masumi Hirabayashi; Hiromitsu Nakauchi
Journal:  Nature       Date:  2017-01-25       Impact factor: 49.962

Review 9.  Tools for experimental and computational analyses of off-target editing by programmable nucleases.

Authors:  X Robert Bao; Yidan Pan; Ciaran M Lee; Timothy H Davis; Gang Bao
Journal:  Nat Protoc       Date:  2020-12-07       Impact factor: 13.491

10.  Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells.

Authors:  Shinsaku Tokuda; Mikio Furuse
Journal:  PLoS One       Date:  2015-03-17       Impact factor: 3.240
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