[Chronobiological parameters, cognitive emotional status and sleep quality in acute stroke].

The night urinary level of 6-sulfatoxymelatonin was assessed in 57 patients in acute ischemic stroke and subarachnoid hemorrhage. The relationship between 6-sulfatoxymelatonin (6-SOMT) and chronobiological parameters, cognitive and emotional status and sleep quality was analyzed. The low levels of 6-SOMT in night urine was revealed and more pronounced in ischemic stroke. The association between low levels of 6-SOMT and domen-specific cognitive impairment, high level of trait anxiety and low sleep quality was found. The deficiency of chronotropic and neuroprotective activity of melatonin may be regarded as a key factor in the development of these pathological phenomena.