Andrei Moroz1, Elenice Deffune. 1. Blood Transfusion Center, Cell Engineering Laboratory, Botucatu Medical School, Universidade Estadual Paulista-UNESP, Botucatu, SP, Brazil; Department of Morphology, Extracellular Matrix Laboratory, Botucatu Biosciences Institute, Universidade Estadual Paulista-UNESP, Botucatu, SP, Brazil. Electronic address: moroz@ibb.unesp.br.
Abstract
BACKGROUND: Platelet-rich plasma has been largely used as a therapeutic option for the treatment of chronic wounds of different etiologies. The enhanced regeneration observed after the use of platelet-rich plasma has been systematically attributed to the growth factors that are present inside platelets' granules. AIM: We hypothesize that the remaining plasma and platelet-bound fibronectin may act as a further bioactive protein in platelet-rich plasma preparations. METHODS: Recent reports were analyzed and presented as direct evidences of this hypotheses. RESULTS: Fibronectin may directly influence the extracellular matrix remodeling during wound repair. This effect is probably through matrix metalloproteinase expression, thus exerting an extra effect on chronic wound regeneration. CONCLUSIONS: Physicians should be well aware of the possible fibronectin-induced effects in their future endeavors with PRP in chronic wound treatment.
BACKGROUND: Platelet-rich plasma has been largely used as a therapeutic option for the treatment of chronic wounds of different etiologies. The enhanced regeneration observed after the use of platelet-rich plasma has been systematically attributed to the growth factors that are present inside platelets' granules. AIM: We hypothesize that the remaining plasma and platelet-bound fibronectin may act as a further bioactive protein in platelet-rich plasma preparations. METHODS: Recent reports were analyzed and presented as direct evidences of this hypotheses. RESULTS:Fibronectin may directly influence the extracellular matrix remodeling during wound repair. This effect is probably through matrix metalloproteinase expression, thus exerting an extra effect on chronic wound regeneration. CONCLUSIONS: Physicians should be well aware of the possible fibronectin-induced effects in their future endeavors with PRP in chronic wound treatment.
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