Literature DB >> 23991674

Construction of multifunctional modules for drug discovery: synthesis of novel thia/oxa-azaspiro[3.4]octanes.

Dong Bo Li1, Mark Rogers-Evans, Erick M Carreira.   

Abstract

New classes of thia/oxa-azaspiro[3.4]octanes are synthesized through the implementation of robust and step-economic routes. The targeted spirocycles have been designed to act as novel, multifunctional, and structurally diverse modules for drug discovery. Furthermore, enantioselective approaches to the spirocycles are reported.

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Year:  2013        PMID： 23991674     DOI： 10.1021/ol402127b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Strain-Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl Ketones.

Authors:  Jasper L Tyler; Adam Noble; Varinder K Aggarwal
Journal:  Angew Chem Int Ed Engl       Date:  2021-04-16       Impact factor: 15.336

2.  Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery.

Authors:  Thomas A King; Hannah L Stewart; Kim T Mortensen; Andrew J P North; Hannah F Sore; David R Spring
Journal:  European J Org Chem       Date:  2019-07-29

3.  Accelerating fragment-based library generation by coupling high-performance photoreactors with benchtop analysis.

Authors:  Quentin Lefebvre; Christophe Salomé; Thomas C Fessard
Journal:  Beilstein J Org Chem       Date:  2020-05-12       Impact factor: 2.883

4.  Oxa-spirocycles: synthesis, properties and applications.

Authors:  Kateryna Fominova; Taras Diachuk; Dmitry Granat; Taras Savchuk; Vladyslav Vilchynskyi; Oleksiy Svitlychnyi; Vladyslav Meliantsev; Igor Kovalchuk; Eduard Litskan; Vadym V Levterov; Valentyn R Badlo; Ruslan I Vaskevych; Alla I Vaskevych; Andrii V Bolbut; Volodymyr V Semeno; Rustam Iminov; Kostiantyn Shvydenko; Anastasiia S Kuznetsova; Yurii V Dmytriv; Daniil Vysochyn; Vasyl Ripenko; Andrei A Tolmachev; Olexandra Pavlova; Halyna Kuznietsova; Iryna Pishel; Petro Borysko; Pavel K Mykhailiuk
Journal:  Chem Sci       Date:  2021-07-27       Impact factor: 9.825

5.  C-H Insertion via Ruthenium Catalyzed gem-Hydrogenation of 1,3-Enynes.

Authors:  Sebastian Peil; Alejandro Gutiérrez González; Markus Leutzsch; Alois Fürstner
Journal:  J Am Chem Soc       Date:  2022-02-16       Impact factor: 15.419

Review 6.  Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?

Authors:  Daniel J Foley; Adam Nelson; Stephen P Marsden
Journal:  Angew Chem Int Ed Engl       Date:  2016-08-30       Impact factor: 15.336
  6 in total

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