Ting Xu1, Wenying Xia, Guodong Rong, Shiyang Pan, Peijun Huang, Bing Gu. 1. Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; ; National Key Clinical Department of Laboratory Medicine, Nanjing 210029, China.
Abstract
OBJECTIVES: To investigate the changes in resistance of Acinetobacter baumanni (A. baumannii) to different antimicrobial agents and the association of resistance rates with several independent factors: specimen origin, hospital wards, patients' gender and age, from 2008 to 2011. METHODS: Bacterial isolates were isolated from January 2008 to December 2011 in the First Affiliated Hospital of Nanjing Medical University. Antimicrobial susceptibility testing was determined by the Kirby-Bauer Disk Diffusion Agar method as recommended by CLSI. Data were managed by the software WHONET 5.4 and analyzed by SPSS 17.0 software. RESULTS: The proportion of A. baumannii in our hospital increased from 7.0% in 2008 to 18.8% in 2011, becoming the most frequent pathogen in gram-negative isolates. 79.9% of A. baumannii were cultured from respiratory tract and geriatrics showed the highest isolation rate of A. baumannii during 4 years. The resistance rates to 12 antibiotics significantly increased from 2008 to 2011, from 14.8% to 90.8% to imipenem, and from 23.3% to 91.1% to meropenem. Statistical analysis demonstrated that the specimen origin, hospital wards, patients' gender and age were associated with resistance rate in varying degrees. CONCLUSIONS: The 4-year surveillance of antimicrobial susceptibility demonstrated the rapid increase of drug-resistant strains of A. baumannii, and revealed several factors related with resistance rate. Knowing the antimicrobial resistance patterns will help guide the empirical therapy and strengthen interventional infection control measures in China.
OBJECTIVES: To investigate the changes in resistance of Acinetobacter baumanni (A. baumannii) to different antimicrobial agents and the association of resistance rates with several independent factors: specimen origin, hospital wards, patients' gender and age, from 2008 to 2011. METHODS: Bacterial isolates were isolated from January 2008 to December 2011 in the First Affiliated Hospital of Nanjing Medical University. Antimicrobial susceptibility testing was determined by the Kirby-Bauer Disk Diffusion Agar method as recommended by CLSI. Data were managed by the software WHONET 5.4 and analyzed by SPSS 17.0 software. RESULTS: The proportion of A. baumannii in our hospital increased from 7.0% in 2008 to 18.8% in 2011, becoming the most frequent pathogen in gram-negative isolates. 79.9% of A. baumannii were cultured from respiratory tract and geriatrics showed the highest isolation rate of A. baumannii during 4 years. The resistance rates to 12 antibiotics significantly increased from 2008 to 2011, from 14.8% to 90.8% to imipenem, and from 23.3% to 91.1% to meropenem. Statistical analysis demonstrated that the specimen origin, hospital wards, patients' gender and age were associated with resistance rate in varying degrees. CONCLUSIONS: The 4-year surveillance of antimicrobial susceptibility demonstrated the rapid increase of drug-resistant strains of A. baumannii, and revealed several factors related with resistance rate. Knowing the antimicrobial resistance patterns will help guide the empirical therapy and strengthen interventional infection control measures in China.
Authors: Young Kyoung Park; Sook-In Jung; Kyong-Hwa Park; Dae Hun Kim; Ji Young Choi; Su Hwan Kim; Kwan Soo Ko Journal: J Med Microbiol Date: 2011-08-18 Impact factor: 2.472
Authors: Maria Cristina Bronharo Tognim; Soraya Sgambatti Andrade; Suzane Silbert; Ana Cristina Gales; Ronald N Jones; Hélio S Sader Journal: Int J Infect Dis Date: 2004-09 Impact factor: 3.623
Authors: Rebecca H Sunenshine; Marc-Oliver Wright; Lisa L Maragakis; Anthony D Harris; Xiaoyan Song; Joan Hebden; Sara E Cosgrove; Ashley Anderson; Jennifer Carnell; Daniel B Jernigan; David G Kleinbaum; Trish M Perl; Harold C Standiford; Arjun Srinivasan Journal: Emerg Infect Dis Date: 2007-01 Impact factor: 6.883
Authors: Ji Ye Jung; Moo Suk Park; Song Ee Kim; Byung Hoon Park; Ji Young Son; Eun Young Kim; Joo Eun Lim; Sang Kook Lee; Sang Hoon Lee; Kyung Jong Lee; Young Ae Kang; Se Kyu Kim; Joon Chang; Young Sam Kim Journal: BMC Infect Dis Date: 2010-07-30 Impact factor: 3.090