BACKGROUND: Glycemic control affects cardiovascular risk factors positively. The purpose of this study was to assess B-type natriuretic peptide (BNP) levels in patients with poorly controlled diabetes before and after glycemic regulation was achieved. METHODS: The study was performed in a prospective design. The study population consisted of 79 consecutive diabetic patients with poor glycemic control. All subjects underwent transthoracic echocardiography. Levels of fasting plasma glucose, glycosylated hemoglobin (HbA1c), lipid parameters, and BNP were measured before the onset of the treatment and after glycemic regulation was achieved. RESULTS: A significant decrease in BNP (95.0 [4.0-1807] ng/L vs. 52.0 [2.1-987.0] ng/L, p < 0.001) levels were observed, after improving glycemic control. The decrease in BNP levels was positively correlated with the decrease in HbA1c (r = 0.345, p = 0.003) and fasting plasma glucose (r = 0.366, p = 0.002). There was no correlation between the decrease in BNP levels and lipid parameters (p = NS). CONCLUSIONS: We conclude that poor glycemic control may cause high levels of BNP which may lead to overdiagnosis of congestive heart failure. We suggest that HbA1c and fasting plasma glucose should be checked in patients with high levels of BNP.
BACKGROUND: Glycemic control affects cardiovascular risk factors positively. The purpose of this study was to assess B-type natriuretic peptide (BNP) levels in patients with poorly controlled diabetes before and after glycemic regulation was achieved. METHODS: The study was performed in a prospective design. The study population consisted of 79 consecutive diabeticpatients with poor glycemic control. All subjects underwent transthoracic echocardiography. Levels of fasting plasma glucose, glycosylated hemoglobin (HbA1c), lipid parameters, and BNP were measured before the onset of the treatment and after glycemic regulation was achieved. RESULTS: A significant decrease in BNP (95.0 [4.0-1807] ng/L vs. 52.0 [2.1-987.0] ng/L, p < 0.001) levels were observed, after improving glycemic control. The decrease in BNP levels was positively correlated with the decrease in HbA1c (r = 0.345, p = 0.003) and fasting plasma glucose (r = 0.366, p = 0.002). There was no correlation between the decrease in BNP levels and lipid parameters (p = NS). CONCLUSIONS: We conclude that poor glycemic control may cause high levels of BNP which may lead to overdiagnosis of congestive heart failure. We suggest that HbA1c and fasting plasma glucose should be checked in patients with high levels of BNP.
Authors: Tim Hollstein; Kristina Schlicht; Laura Krause; Stefanie Hagen; Nathalie Rohmann; Dominik M Schulte; Kathrin Türk; Alexia Beckmann; Markus Ahrens; Andre Franke; Stefan Schreiber; Thomas Becker; Jan Beckmann; Matthias Laudes Journal: Sci Rep Date: 2021-05-12 Impact factor: 4.379
Authors: Yuen-Kwun Wong; Chloe Y Y Cheung; Clara S Tang; JoJo S H Hai; Chi-Ho Lee; Kui-Kai Lau; Ka-Wing Au; Bernard M Y Cheung; Pak-Chung Sham; Aimin Xu; Karen S L Lam; Hung-Fat Tse Journal: Cardiovasc Diabetol Date: 2019-12-17 Impact factor: 9.951
Authors: Esraa M Zakaria; Walaa M Tawfeek; Mohamed H Hassanin; Mohammed Y Hassaballah Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2022-08-10 Impact factor: 3.195